Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo- and radio-therapy in solid tumors. Pre-clinical and clinical research studies have demonstrated that targeted hyperthermia can increase tumor blood flow and increase the perfused fraction of the tumor in a temperature and time dependent manner. Changes in tumor blood circulation can produce significant physiological changes including enhanced vascular permeability, increased oxygenation, decreased interstitial fluid pressure, and reestablishment of normal physiological pH conditions. These alterations in tumor physiology can positively impact both small molecule and nanomedicine chemotherapy accumulation and distribution within the tumor, as well as the fraction of the tumor susceptible to radiation therapy. Hyperthermia can trigger drug release from thermosensitive formulations and further improve the accumulation, distribution, and efficacy of chemotherapy.

热疗已证明在提高实体瘤化疗和放疗疗效方面的临床成功。临床前和临床研究表明，靶向热疗可以增加肿瘤血流量，并以温度和时间依赖的方式增加肿瘤的灌注部分。肿瘤血液循环的变化可产生显着的生理变化，包括血管通透性增强、氧合增加、间质液压力降低和正常生理 pH 条件的重建。肿瘤生理学的这些改变可以积极影响小分子和纳米药物化疗在肿瘤内的积累和分布，以及对放射治疗敏感的肿瘤部分。