Morphology Regulation of Monosodium Urate Monohydrate Crystals via Fabricated Uniform Hydrogel Slices,Crystal Research and Technology

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Morphology Regulation of Monosodium Urate Monohydrate Crystals via Fabricated Uniform Hydrogel Slices
Crystal Research and Technology ( IF 1.5 ) Pub Date : 2020-07-12 , DOI: 10.1002/crat.202000039
Zeqiu Xia ₁ , Lin Wang ₁ , Gaohong He ₁ , Xiaobin Jiang ₁

Affiliation

Crystal morphology control is a common concern for the crystal engineering and relevant applications. For example, urate crystallization is important for the study of the hyperuricemia induced gout. Herein, biomimetic hydrogel material with uniform surface and vertical structure is fabricated, which possesses hybrid pH‐temperature responsibility for high‐efficiency interfacial nucleation and concentration regulation functions. The developed hydrogel layers are prepared to slice type as a functional microplatform and then added into the uric acid dihydrate (UAD) crystal solution to induce monosodium urate monohydrate (MSUM) crystallization. With different dosage of the hydrogel slices (HGS) in the solution, diverse crystal morphologies can be obtained in an efficient manner, such as “flower,” “sphere,” “sticky spheres,” which entirely distinguishes from the one prepared via no‐HGS. This work explores a new path for revealing the relevant crystallization mechanism and developing crystal morphology control technology with hydrogel interfacial materials.

中文翻译：

尿素一水合一水合物晶体的均匀结构水凝胶切片的形态学调控

晶体形态控制是晶体工程和相关应用的共同关注点。例如，尿酸盐结晶对于高尿酸血症引起的痛风的研究很重要。在此，制造出具有均匀表面和垂直结构的仿生水凝胶材料，该材料具有混合的pH温度特性，可实现高效的界面成核和浓度调节功能。将显影的水凝胶层制备成片状，作为功能性微平台，然后添加到尿酸二水合物（UAD）晶体溶液中，以诱导尿酸钠一水合物（MSUM）结晶。通过在溶液中使用不同剂量的水凝胶切片（HGS），可以有效地获得各种晶体形态，例如“花”，“球”，“粘性球”，“ ”完全不同于通过no-HGS所准备的。这项工作探索了揭示相关结晶机理和开发水凝胶界面材料的晶体形态控制技术的新途径。

更新日期：2020-07-12

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