<br>具有视觉刺激响应结构颜色变化的智能药物输送微粒。,International Journal of Nanomedicine

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具有视觉刺激响应结构颜色变化的智能药物输送微粒。
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-07-12 , DOI: 10.2147/ijn.s249009
Xiaoyan Sun ₁ , Lingzi Liu ₁ , Hui Zou ₁ , Caixia Yao ₁ , Zhengyu Yan ₁ , Baofen Ye ₁

Affiliation

背景：基于颗粒的药物递送系统（DDS）在药物发现和开发方面具有已被证明的价值。然而，一些问题仍有待解决，例如刺激有限、视觉监控等。

目的：开发一种具有近红外 (NIR) 控制释放和宏观颜色变化的智能多色 DDS。

材料和方法：以 SCCBs 为模板，合成包含 GO/pNIPAM/PEGDA 复合水凝胶反蛋白石支架、葡聚糖和海藻酸钙水凝胶的微粒。在扫描电子显微镜下观察微粒的形态，并使用共焦激光扫描显微镜测定FITC-葡聚糖衍生的绿色荧光图像。在药物释放过程中，使用荧光倒置显微镜捕获 FITC-葡聚糖衍生的绿色荧光图像。利用光密度（OD）值的变化获得近红外功率与药物释放速率之间的关系。最后，可以利用结构色或反射峰位置定量估计药物的释放量。

结果：基于适当的体积收缩率和结构颜色之间的平衡，选择固定浓度8%（v/v）的PEGDA和4mg/mL的GO作为最佳浓度。使用 0.2 wt% 海藻酸钠将 FITC-葡聚糖均匀封装在颗粒中。微载体因光热响应而收缩，同时微粒中FITC-葡聚糖的固有荧光强度逐渐降低，表明药物释放。随着近红外辐射持续时间的增加，微粒逐渐收缩，反射峰向蓝色移动，结构颜色依次从红色变为橙色、黄色、绿色、青色和蓝色。通过微粒的结构颜色可以预测药物的释放量。

结论：多色微粒具有鲜艳的报告颜色、优异的光热效应和良好的刺激响应性，在药物递送系统中具有巨大的潜力。

"点击查看英文标题和摘要"

Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.

Background: Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development. However, some problems remain to be solved, such as limited stimuli, visual-monitoring.
Aim: To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
Materials and Methods: Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template. The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope. During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope. The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values. Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
Results: A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color. The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate. The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release. With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively. The drug release quantity can be predicted by the structural color of microparticles.
Conclusion: The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.

更新日期：2020-07-13

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