Production of Propene from n-Butanol: A Three-Step Cascade Utilizing the Cytochrome P450 Fatty Acid Decarboxylase OleTJE.,ChemBioChem

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Production of Propene from n-Butanol: A Three-Step Cascade Utilizing the Cytochrome P450 Fatty Acid Decarboxylase OleTJE.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-07-12 , DOI: 10.1002/cbic.202000378
Daniel Bauer ₁ , Ioannis Zachos ₁ , Volker Sieber _{1,

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Affiliation

Propelled to propene: Propene is produced in a three‐step enzymatic cascade from n‐butanol via butanal and butyric acid, with the last step being oxidative decarboxylation catalyzed by OleT_JE. Variation of the supply of redox donors demonstrates the peroxygenase nature of OleT_JE. A mutational study led to a new variant, OleT_V292I, which shows significantly higher activity towards the short‐chain substrate.

中文翻译：

从正丁醇生产丙烯：利用细胞色素 P450 脂肪酸脱羧酶 OleTJE 的三步级联。

推进为丙烯：丙烯是由正丁醇通过丁醛和丁酸通过三步酶级联生产的，最后一步是 OleT _JE催化的氧化脱羧。氧化还原供体供应的变化证明了 OleT _JE的过氧化酶性质。一项突变研究产生了一种新的变体 OleT _V292I，它对短链底物表现出显着更高的活性。

更新日期：2020-07-12

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