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pH‐responsive chitosan/sulfobutyl ether‐β‐cyclodextrin supramolecular nanoparticles for controlled release of sodium ferulate
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-07-09 , DOI: 10.1002/pen.25479 Lulu Yue 1 , Wen Jin 1 , Shaoming Chi 1 , Tong Yang 1 , Ze Lei 2 , Hongyou Zhu 2 , Yan Zhao 1
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-07-09 , DOI: 10.1002/pen.25479 Lulu Yue 1 , Wen Jin 1 , Shaoming Chi 1 , Tong Yang 1 , Ze Lei 2 , Hongyou Zhu 2 , Yan Zhao 1
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A pH‐responsive supramolecular nanoparticles was constructed through the electrostatic interaction from anionic sulfobutyl ether‐β‐cyclodextrin (SBE7‐β‐CD) and two positively charged chitosan (CS‐75% and CS‐95%). The prepared nanoparticles were characterized by UV‐vis absorption spectra, x‐ray diffraction, dynamic light scattering, transmission electron microscopy, and zeta potential. It was found that the CS/SBE7‐β‐CD nanoparticles can be disassembly by increasing pH value and reassembled by reducing to the original pH value. To explore the potential of the obtained nanoparticles as a drug delivery vehicle, a negatively charged anticardio cerebrovascular drug sodium ferulate (SF) was loaded. The result indicated that the SF could be efficiently encapsulated in its nanoparticle nucleus under simulated gastric conditions with lower pH (pH 2.0), while effective release is triggered in a simulated intestinal environment with higher pH (pH 8.5). The assembly/disassembly behavior and drug loading/release property make CS/SBE7‐β‐CD nanoparticles promising candidates for pH stimulation responsive drug delivery system, which has a broad application prospect in the treatment of cardiovascular and cerebrovascular diseases, diabetes and other chronic diseases.
中文翻译：
pH响应的壳聚糖/磺基丁基醚-β-环糊精超分子纳米颗粒可控制阿魏酸钠的释放
pH响应超分子的纳米颗粒通过选自阴离子磺丁基醚-β环糊精（SBE的静电相互作用构建7 -β-CD）和两个正电荷的壳聚糖（CS-75％和CS-95％）。制备的纳米颗粒通过紫外可见吸收光谱，X射线衍射，动态光散射，透射电子显微镜和ζ电位进行表征。发现CS / SBE 7可以通过增加pH值来分解β-CD纳米颗粒，并通过降低到原始pH值来重新组装。为了探索获得的纳米颗粒作为药物递送载体的潜力，加载了带负电荷的抗心脑血管药物阿魏酸钠（SF）。结果表明，在较低pH（pH 2.0）的模拟胃条件下，SF可以有效地包封在其纳米颗粒核中，而在较高pH（pH 8.5）的模拟肠环境中可以触发有效释放。CS / SBE 7的组装/拆卸性能和载药/释放特性β-CD纳米颗粒有望成为pH刺激响应型药物输送系统的候选药物，在治疗心脑血管疾病，糖尿病和其他慢性疾病方面具有广阔的应用前景。
更新日期：2020-07-09
中文翻译：
pH响应的壳聚糖/磺基丁基醚-β-环糊精超分子纳米颗粒可控制阿魏酸钠的释放
pH响应超分子的纳米颗粒通过选自阴离子磺丁基醚-β环糊精（SBE的静电相互作用构建7 -β-CD）和两个正电荷的壳聚糖（CS-75％和CS-95％）。制备的纳米颗粒通过紫外可见吸收光谱，X射线衍射，动态光散射，透射电子显微镜和ζ电位进行表征。发现CS / SBE 7可以通过增加pH值来分解β-CD纳米颗粒，并通过降低到原始pH值来重新组装。为了探索获得的纳米颗粒作为药物递送载体的潜力，加载了带负电荷的抗心脑血管药物阿魏酸钠（SF）。结果表明，在较低pH（pH 2.0）的模拟胃条件下，SF可以有效地包封在其纳米颗粒核中，而在较高pH（pH 8.5）的模拟肠环境中可以触发有效释放。CS / SBE 7的组装/拆卸性能和载药/释放特性β-CD纳米颗粒有望成为pH刺激响应型药物输送系统的候选药物，在治疗心脑血管疾病，糖尿病和其他慢性疾病方面具有广阔的应用前景。
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