The effects of fluoride on endocrine tissues has not been sufficiently explored to date. The current body of knowledge suggest significant effects of that mineral on reducing sex hormone levels, which may consequently impair fertility and disrupt puberty. The majority of studies confirm that sodium fluoride increases TSH levels and decreases the concentrations of T3 and T4 produced by the thyroid. Moreover, a correlation was observed between NaF and increased secretion of PTH by the parathyroid glands, without a significant impact on body calcium levels. Probably, fluoride may exert adverse effects on insulin levels, impairing pancreatic function and resulting in abnormal glucose tolerance. Observations also include decreased levels of cortisol secreted by the adrenal glands. In light of the few existing studies, the mechanism of fluoride toxicity on the endocrine system has been described.

迄今为止，氟化物对内分泌组织的作用尚未得到充分的研究。当前的知识表明该矿物质对降低性激素水平具有显著作用，因此可能损害生育力并破坏青春期。大多数研究证实，氟化钠可增加甲状腺激素的水平，并降低甲状腺产生的T3和T4的浓度。此外，观察到NaF与甲状旁腺分泌的PTH增加之间存在相关性，而对人体钙水平没有显着影响。氟化物可能会对胰岛素水平产生不利影响，损害胰腺功能并导致异常的葡萄糖耐量。观察结果还包括肾上腺分泌的皮质醇水平降低。根据现有的一些研究，