当前位置：
X-MOL 学术
›
J. Nat. Prod.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-07-08 , DOI: 10.1021/acs.jnatprod.9b00947 Masahiko Isaka 1 , Panida Chinthanom 1 , Rattaket Choeyklin 1 , Tuksaporn Thummarukcharoen 2 , Pranee Rachtawee 1 , Malipan Sappan 1 , Kitlada Srichomthong 1 , Ryoma Fujii 3 , Kyohei Kawashima 3 , Seiji Mori 3
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-07-08 , DOI: 10.1021/acs.jnatprod.9b00947 Masahiko Isaka 1 , Panida Chinthanom 1 , Rattaket Choeyklin 1 , Tuksaporn Thummarukcharoen 2 , Pranee Rachtawee 1 , Malipan Sappan 1 , Kitlada Srichomthong 1 , Ryoma Fujii 3 , Kyohei Kawashima 3 , Seiji Mori 3
Affiliation
|
The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A–H (1–8) and ganodermalactones T–X (9–13), together with 23 known compounds (14–36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.
中文翻译：
来自木腐病担子菌 Ganoderma colossus 的高度改性羊毛脂烷三萜：天然和人工培养的子实体和菌丝体培养物的比较化学研究。
已经对木腐担子菌Ganoderma colossus进行了化学研究。对天然子实体、人工培养子实体和菌丝体培养物的比较分析导致总共分离出 13 种新的高度修饰羊毛脂素、ganocolossusins A–H ( 1 – 8 ) 和灵芝内酯T–X ( 9 – 13 ) ，连同 23 种已知化合物 ( 14 – 36 )。真菌材料的三种不同状态之间存在相同化合物的显着重叠。Ganocolossusin D ( 4 ) 对恶性疟原虫表现出最有效的抗疟活性K1（多重耐药菌株）的 IC 50值为 2.4 μM，而在 50 μg/mL 时对 Vero 细胞无细胞毒性。
更新日期：2020-07-24
中文翻译：
来自木腐病担子菌 Ganoderma colossus 的高度改性羊毛脂烷三萜：天然和人工培养的子实体和菌丝体培养物的比较化学研究。
已经对木腐担子菌Ganoderma colossus进行了化学研究。对天然子实体、人工培养子实体和菌丝体培养物的比较分析导致总共分离出 13 种新的高度修饰羊毛脂素、ganocolossusins A–H ( 1 – 8 ) 和灵芝内酯T–X ( 9 – 13 ) ，连同 23 种已知化合物 ( 14 – 36 )。真菌材料的三种不同状态之间存在相同化合物的显着重叠。Ganocolossusin D ( 4 ) 对恶性疟原虫表现出最有效的抗疟活性K1（多重耐药菌株）的 IC 50值为 2.4 μM，而在 50 μg/mL 时对 Vero 细胞无细胞毒性。
京公网安备 11010802027423号