新型单808 nm NIR光诱导成像引导多功能癌症治疗平台,Advanced Functional Materials

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新型单808 nm NIR光诱导成像引导多功能癌症治疗平台
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2015-05-22 , DOI: 10.1002/adfm.201500464
Fei He ₁ , Guixin Yang ₁ , Piaoping Yang ₁ , Yuxiu Yu ₁ , Ruichan Lv ₁ , Chunxia Li ₂ , Yunlu Dai ₁ , Shili Gai ₁ , Jun Lin ₂

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近红外光诱导成像指导的癌症治疗是靶向癌症治疗领域中的一种有前途的途径。但是，到目前为止，现有的单模态光诱导成像效果还不足以满足更高的诊断要求。因此，非常需要具有多模光诱导成像效果的多功能癌症治疗平台。在这项工作中，首次将卡托普利稳定化的Au纳米团簇Au ₂₅（Capt）_18-（Au ₂₅）组装到Nd ³⁺敏化上转换纳米粒子（UCNPs）外部的介孔二氧化硅壳涂层中。新组建的Au ₂₅壳显示出显着的光热效应，带来了光热成像和光声成像特性，同时还具有上转换发光成像。更重要的是，可以通过用单个NIR光（808 nm）激发来同时获得三种光诱导的成像效果，这也是光热和光动力癌症治疗的触发因素。此外，由于Gd ³⁺和Yb ^3+的存在，纳米颗粒还可以表现出磁共振和计算机断层成像的效果。UCNP中的离子。此外，由于光动力和光热效应，纳米颗粒在808nm光的单次照射下具有有效的体内肿瘤生长抑制作用。具有多模式成像效果的多功能癌症治疗平台可实现真正意义上的光诱导成像指导的癌症治疗。

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A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform

The NIR light‐induced imaging‐guided cancer therapy is a promising route in the targeting cancer therapy field. However, up to now, the existing single‐modality light‐induced imaging effects are not enough to meet the higher diagnosis requirement. Thus, the multifunctional cancer therapy platform with multimode light‐induced imaging effects is highly desirable. In this work, captopril stabilized‐Au nanoclusters Au₂₅(Capt)₁₈−(Au₂₅) are assembled into the mesoporous silica shell coating outside of Nd³⁺‐sensitized upconversion nanoparticles (UCNPs) for the first time. The newly formed Au₂₅ shell exhibits considerable photothermal effects, bringing about the photothermal imaging and photoacoustic imaging properties, which couple with the upconversion luminescence imaging. More importantly, the three light‐induced imaging effects can be simultaneously achieved by exciting with a single NIR light (808 nm), which is also the triggering factor for the photothermal and photodynamic cancer therapy. Besides, the nanoparticles can also present the magnetic resonance and computer tomography imaging effects due to the Gd³⁺ and Yb³⁺ ions in the UCNPs. Furthermore, due to the photodynamic and the photothermal effects, the nanoparticles possess efficient in vivo tumor growth inhibition under the single irradiation of 808 nm light. The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light‐induced imaging‐guided cancer therapy.

更新日期：2015-05-22

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