Five new 19-acetoxyingols were isolated from the aerial parts of Euphorbia saudiarabica. They included two uncommon pentacyclic acetoxyingols (1, 2) and two 2,3-diepimers (3, 4), representing the first report of 19-acetoxyingols epimers. Their structures were determined by analysis of extensive 1D and 2D NMR spectroscopic data. The absolute configurations were established by experimental and calculated CD analysis. Compounds 3–5 showed α-glucosidase inhibitory effects superior to the positive control, acarbose (IC₅₀ 9.1, 8.0, 1.8 vs 147 µM, respectively). Compounds 1, 2, 4, and 5 showed inhibitory effects on human P-glycoprotein comparable to the positive control, valspodar (IC₅₀ 0.1–1.4 vs 0.2 µM, respectively).

从大戟大戟的地上部分中分离出五种新的19-乙酰氧基丁酚。它们包括两个非五环acetoxyingols（1，2）和两个2,3- diepimers（3，4），较19差向异构体acetoxyingols的第一份报告。通过分析广泛的1D和2D NMR光谱数据确定了它们的结构。通过实验和计算的CD分析来建立绝对构型。化合物3 - 5表明α葡萄糖苷酶优于阳性对照，阿卡波糖（IC抑制作用₅₀分别9.1，8.0，1.8 VS 147μM）。化合物1，2，图4和图5显示了对人P糖蛋白的抑制作用，与​​阳性对照valspodar相当（IC ₅₀分别为0.1–1.4和0.2 µM）。