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Oligo(l-glutamic acids) in Calcium Phosphate Precipitation: Mechanism of Delayed Phase Transformation.
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2020-06-29 , DOI: 10.1021/acs.jpcb.0c01690 Putu Ustriyana 1 , F Marc Michel 2 , Michael C Wilson 1 , Emma Harmon 1 , Jiahui Chen 1 , Tianbo Liu 1 , Nita Sahai 1, 3, 4
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2020-06-29 , DOI: 10.1021/acs.jpcb.0c01690 Putu Ustriyana 1 , F Marc Michel 2 , Michael C Wilson 1 , Emma Harmon 1 , Jiahui Chen 1 , Tianbo Liu 1 , Nita Sahai 1, 3, 4
Affiliation
Proteins and their mimics that contain negatively charged sequences are important in natural and biomimetic mineralization. The mechanism by which these sequences affect calcium phosphate mineralization is not well understood. Here, peptides containing different numbers of repeat units of contiguous glutamic acid residues, oligo(l-glutamic acid)n (n = 3, 7, 8, 10), were investigated with regards to the mechanism in delaying the crystallization of amorphous calcium phosphate (ACP) while holding the amount of carboxylic acid groups in solution constant. Increasing peptide chain length increases the stability of ACP at a certain total amount of carboxylic acid groups in solution. This effect is shown to be due to stronger binding as well as binding to more calcium ions per peptide by the longer oligopeptides compared to the shorter ones. It is proposed that these associations delay the structural rearrangement of calcium ions and the dehydration of ACP, which are required for the crystallization of hydroxyapatite. The initial nucleation and the local structure of ACP, however, do not vary with chain length. This second part of a two-part series provides an improved mechanistic understanding of how organic additives, especially those with contiguous acidic amino acid sequences, modulate the kinetics of calcium phosphate precipitation and phase transformation.
中文翻译:
磷酸钙沉淀中的低聚(1-谷氨酸):延迟相变的机理。
含有负电荷序列的蛋白质及其模拟物在自然和仿生矿化中很重要。这些序列影响磷酸钙矿化的机制尚不清楚。在此,包含连续谷氨酸残基的重复单元数目不同的肽寡聚(l-谷氨酸)n(n研究了在使溶液中的羧酸基团数量保持恒定的同时延迟无定形磷酸钙(ACP)结晶的机理方面的研究(= 3、7、8、10)。肽链长度的增加增加了溶液中一定数量的羧酸基团时ACP的稳定性。结果表明,与较短的寡肽相比,较长的寡肽具有更强的结合力,并且与每个肽结合更多的钙离子,是由于这种作用。提出这些缔合延迟了钙磷灰石结晶所需的钙离子的结构重排和ACP的脱水。但是,ACP的初始成核和局部结构不会随链长而变化。
更新日期:2020-07-23
中文翻译:
磷酸钙沉淀中的低聚(1-谷氨酸):延迟相变的机理。
含有负电荷序列的蛋白质及其模拟物在自然和仿生矿化中很重要。这些序列影响磷酸钙矿化的机制尚不清楚。在此,包含连续谷氨酸残基的重复单元数目不同的肽寡聚(l-谷氨酸)n(n研究了在使溶液中的羧酸基团数量保持恒定的同时延迟无定形磷酸钙(ACP)结晶的机理方面的研究(= 3、7、8、10)。肽链长度的增加增加了溶液中一定数量的羧酸基团时ACP的稳定性。结果表明,与较短的寡肽相比,较长的寡肽具有更强的结合力,并且与每个肽结合更多的钙离子,是由于这种作用。提出这些缔合延迟了钙磷灰石结晶所需的钙离子的结构重排和ACP的脱水。但是,ACP的初始成核和局部结构不会随链长而变化。