Transdermal drug delivery (TDD) has gained attention over the past decades as a pain-free drug administration path. Various drug release control mechanisms have also been developed for the advanced application of TDD. However, most controlled delivery systems depend on external stimuli such as temperature, pH and so on; making the design complicated and more expensive. In this study, we prepared mussel inspired self-adhesive hydrogel for monolith, drug in adhesive, strain-controlled transdermal delivery using a simple and effective method. The synthesis method involves modifying alginate with gallic acid followed by in-situ polymerization of polyacrylic acid. The resulting hydrogel (GA) is a heavily intertwined, interpenetrating supramolecular network mainly due to the numerous hydrogen bonds. It is extremely stretchable (800% strain) and adheres strongly on polymer, glass, and metal under both wet and dry conditions. Additionally, it has a layered and highly porous internal structure providing excellent elasticity and efficient drug delivery. Kinetic experiment results show that 77.47%, 82.09%, 87.64% and 42.54% of pre-loaded caffeine in GA is released within an hour under 100%, 50%, 25%, and 0% tensile strain, respectively. These results demonstrate that GA is a potential self-adhesive matrix for strain controlled TDD for caffeine possibly for other drugs as well.

在过去的几十年中，经皮给药（TDD）作为一种无痛的给药途径已受到关注。还已经开发出各种药物释放控制机制用于TDD的高级应用。但是，大多数受控递送系统取决于外部刺激，例如温度，pH等。使设计复杂且昂贵。在这项研究中，我们使用一种简单有效的方法制备了贻贝启发性自粘性水凝胶，用于整料，粘合剂中的药物，应变控制的透皮给药。合成方法包括用没食子酸改性藻酸盐，然后进行聚丙烯酸的原位聚合。产生的水凝胶（GA）是高度缠结，互穿的超分子网络，主要是由于存在大量氢键。它具有极好的可拉伸性（800％应变），在湿和干条件下均能牢固地粘附在聚合物，玻璃和金属上。此外，它具有层状和高度多孔的内部结构，可提供出色的弹性和有效的药物输送。动力学实验结果表明，GA中预装咖啡因的77.47％，82.09％，87.64％和42.54％分别在一小时内在100％，50％，25％和0％拉伸应变下释放。这些结果表明，GA是咖啡因可能通过应变控制的TDD的潜在自粘基质，可能还用于其他药物。在一小时内，分别在100％，50％，25％和0％拉伸应变下释放了54％的GA中预加载的咖啡因。这些结果表明，GA是咖啡因可能通过应变控制的TDD的潜在自粘基质，可能还用于其他药物。在一小时内，分别在100％，50％，25％和0％拉伸应变下释放了54％的GA中预加载的咖啡因。这些结果表明，GA是咖啡因可能通过应变控制的TDD的潜在自粘基质，可能还用于其他药物。