当前位置：
X-MOL 学术
›
Nano Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria.
Nano Letters ( IF 9.6 ) Pub Date : 2020-06-23 , DOI: 10.1021/acs.nanolett.0c01371 Shenqiang Wang 1 , Hua Zheng 1 , Li Zhou 1 , Fang Cheng 1 , Zhao Liu 1 , Hepeng Zhang 1 , Lili Wang 2 , Qiuyu Zhang 1, 3
Nano Letters ( IF 9.6 ) Pub Date : 2020-06-23 , DOI: 10.1021/acs.nanolett.0c01371 Shenqiang Wang 1 , Hua Zheng 1 , Li Zhou 1 , Fang Cheng 1 , Zhao Liu 1 , Hepeng Zhang 1 , Lili Wang 2 , Qiuyu Zhang 1, 3
Affiliation
|
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed to simultaneously overcome these hurdles. The FEMI hydrogel was fabricated through a Schiff-based reaction between ε-polylysine (EPL)-coated MnO2 nanosheets (EM) and insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through a synergistic combination of EPL and “nanoknife-like” MnO2 nanosheets, the FEMI hydrogel exhibited extraordinary antimicrobial capacities against MDR bacteria. The MnO2 nanoenzyme reshaped the hostile oxidative wound microenvironment by decomposing the endogenous H2O2 into O2. Meanwhile, the pH/redox dual-responsive FEMI hydrogel achieved a sustained and spatiotemporal controlled release of insulin to regulate the blood glucose. Our FEMI hydrogel demonstrated an accelerated MDR bacteria-infected diabetic wound healing in vivo and represents a versatile strategy for healing a broad range of tissue damages caused by diabetes.
中文翻译：
纳米酶增强的可注射水凝胶，用于治愈感染了多药耐药细菌的糖尿病伤口。
糖尿病伤口愈合由于其易受多重耐药性（MDR）细菌感染以及高血糖和氧化性伤口微环境的影响，仍然是一项关键挑战。本文中，开发了可注射的多功能水凝胶（FEMI）以同时克服这些障碍。FEMI水凝胶是通过ε-聚赖氨酸（EPL）包覆的MnO 2纳米片（EM）和负载胰岛素的自组装醛Pluronic F127（FCHO）胶束之间基于席夫（Schiff）的反应制备的。通过EPL和“纳米刀状” MnO 2纳米片的协同组合，FEMI水凝胶对MDR细菌表现出非凡的抗菌能力。MnO 2纳米酶通过将内源性H 2 O 2分解为O 2来重塑敌对的氧化伤口微环境。同时，pH /氧化还原双反应FEMI水凝胶实现了胰岛素的持续时空控制释放，以调节血糖。我们的FEMI水凝胶证明了体内感染了MDR细菌的糖尿病伤口愈合加速，并且代表了一种用于治愈由糖尿病引起的广泛组织损伤的通用策略。
更新日期：2020-07-08
中文翻译：
纳米酶增强的可注射水凝胶，用于治愈感染了多药耐药细菌的糖尿病伤口。
糖尿病伤口愈合由于其易受多重耐药性（MDR）细菌感染以及高血糖和氧化性伤口微环境的影响，仍然是一项关键挑战。本文中，开发了可注射的多功能水凝胶（FEMI）以同时克服这些障碍。FEMI水凝胶是通过ε-聚赖氨酸（EPL）包覆的MnO 2纳米片（EM）和负载胰岛素的自组装醛Pluronic F127（FCHO）胶束之间基于席夫（Schiff）的反应制备的。通过EPL和“纳米刀状” MnO 2纳米片的协同组合，FEMI水凝胶对MDR细菌表现出非凡的抗菌能力。MnO 2纳米酶通过将内源性H 2 O 2分解为O 2来重塑敌对的氧化伤口微环境。同时，pH /氧化还原双反应FEMI水凝胶实现了胰岛素的持续时空控制释放，以调节血糖。我们的FEMI水凝胶证明了体内感染了MDR细菌的糖尿病伤口愈合加速，并且代表了一种用于治愈由糖尿病引起的广泛组织损伤的通用策略。
京公网安备 11010802027423号