Biomedical Micro‐/Nanomotors: From Overcoming Biological Barriers to In Vivo Imaging,Advanced Materials

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Biomedical Micro‐/Nanomotors: From Overcoming Biological Barriers to In Vivo Imaging
Advanced Materials ( IF 27.4 ) Pub Date : 2020-06-24 , DOI: 10.1002/adma.202000512
Changyong Gao ₁ , Yong Wang _{2,

3} , Zihan Ye _{2,

3} , Zhihua Lin ₁ , Xing Ma _{2,

3} , Qiang He ₁

Affiliation

Self‐propelled micro‐ and nanomotors (MNMs) have shown great potential for applications in the biomedical field, such as active targeted delivery, detoxification, minimally invasive diagnostics, and nanosurgery, owing to their tiny size, autonomous motion, and navigation capacities. To enter the clinic, biomedical MNMs request the biodegradability of their manufacturing materials, the biocompatibility of chemical fuels or externally physical fields, the capability of overcoming various biological barriers (e.g., biofouling, blood flow, blood–brain barrier, cell membrane), and the in vivo visual positioning for autonomous navigation. Herein, the recent advances of synthetic MNMs in overcoming biological barriers and in vivo motion‐tracking imaging techniques are highlighted. The challenges and future research priorities are also addressed. With continued attention and innovation, it is believed that, in the future, biomedical MNMs will pave the way to improve the targeted drug delivery efficiency.

中文翻译：

生物医学微/纳米电机：从克服生物障碍到体内成像

自驱动微纳米电机（MNM）由于其微小的尺寸、自主运动和导航能力，在生物医学领域显示出巨大的应用潜力，例如主动靶向输送、解毒、微创诊断和纳米外科手术。为了进入临床，生物医学MNM要求其制造材料的生物可降解性、化学燃料或外部物理场的生物相容性、克服各种生物屏障（例如生物污垢、血流、血脑屏障、细胞膜）的能力，以及用于自主导航的体内视觉定位。本文重点介绍了合成 MNM 在克服生物屏障和体内运动跟踪成像技术方面的最新进展。还讨论了挑战和未来的研究重点。随着持续的关注和创新，相信未来生物医学MNM将为提高靶向给药效率铺平道路。

更新日期：2020-06-24

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