Herein, we report a new oxime-based additive (Oxyma-T) with a similar structure to HONM and Oxyma-B for use in peptide synthesis. Oxyma-T produces less racemization than HOBt, HOAt, OxymaPure, and Oxyma-B during the stepwise solution-phase synthesis of Z-Phg-Pro-NH₂. Moreover, it exhibits superior coupling efficiency in comparison to HOBt during the SPPS of an Aib-enkephalin pentapeptide. Racemization during segment coupling follows the order: HOBt>Oxyma-T>OxymaPure>HOAt>Oxyma-B.

中文翻译：

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Oxyma-T，扩大了偶联试剂的库

在本文中，我们报道了一种新的基于肟的添加剂（Oxyma-T），其结构与HONM和Oxyma-B相似，可用于肽合成。在Z-Phg-Pro-NH ₂的逐步溶液相合成过程中，Oxyma-T的消旋化程度低于HOBt，HOAt，OxymaPure和Oxyma-B 。此外，与Aib-脑啡肽五肽SPPS期间的HOBt相比，它具有优异的偶联效率。片段偶联期间的外消旋化遵循以下顺序：HOBt＞ Oxyma-T＞ OxymaPure＞ HOAt＞ Oxyma-B。