Modular Total Synthesis of Farnesyl Analogues of Cell Wall Precursors Lipid I and II Containing the Staphylococcus aureus Pentaglycine Bridge Modification.,The Journal of Organic Chemistry

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Modular Total Synthesis of Farnesyl Analogues of Cell Wall Precursors Lipid I and II Containing the Staphylococcus aureus Pentaglycine Bridge Modification.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-06-22 , DOI: 10.1021/acs.joc.0c01004
Lukas M Wingen ₁ , Marvin Rausch _{2,

3} , Tanja Schneider ₂ , Dirk Menche ₁

Affiliation

A scalable and modular total synthesis of 3-lipid I and 3-lipid II was accomplished by a novel route involving an efficient solid phase synthesis of the peptide fragment and an effective chemoenzymatic attachment of the second sugar moiety. The generality of this route was further documented by the synthesis of an analogue bearing the pentaglycine interpeptidic bridge modification characteristic for the human pathogen Staphylococcus aureus.

中文翻译：

模块化全合成法尼基类似物的细胞壁前体脂质金黄色葡萄球菌戊糖氨酸桥修饰的脂质I和II。

通过一种新颖的途径完成了3-脂质I和3-脂质II的可扩展和模块化的总合成，该途径包括肽片段的有效固相合成和第二糖部分的有效化学酶连接。这条路线的普遍性进一步通过合成具有人类病原体金黄色葡萄球菌的五甘氨酸肽间桥修饰特征的类似物来证明。

更新日期：2020-08-08

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