A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification,Journal of Chemical Education

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A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2020-06-23 , DOI: 10.1021/acs.jchemed.9b01168
Caleb M. T. Kam ₁ , Stephan M. Levonis ₁ , Stephanie S. Schweiker ₁

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The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid–liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by ¹H and ¹³C NMR spectroscopy and thin-layer chromatography.

中文翻译：

视觉有机化学反应：通过费歇尔酯化反应合成4-氨基-3-硝基苯甲酸甲酯

4-氨基-3-硝基苯甲酸甲酯的合成是一个简单的费歇尔酯化反应，设计用作有机有机化学入门课程的实验。该化合物在30分钟至16小时内以一锅法合成，反应1小时可产生产率。明亮的黄色固体使用液-液萃取进行纯化，萃取过程通过明显的颜色变化进行监控。然后通过¹ H和¹³ C NMR光谱和薄层色谱对产物进行表征。

更新日期：2020-07-14

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