Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes,Advanced Synthesis & Catalysis

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Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-06-22 , DOI: 10.1002/adsc.202000360
Qian Zeng ₁ , Ciwang He ₁ , Su Zhou ₂ , Kuiyong Dong ₁ , Lihua Qiu ₁ , Xinfang Xu _{1,

2}

Affiliation

An efficient dirhodium(II)‐catalyzed macrocyclization reaction of alkyne‐containing diazoacetates through intramolecular metal carbene cyclopropanation is described. This method provides a variety of 12‐ to 22‐membered macrocyclic alkynes, which incorporate ortho‐aryl, cyclopropane, and cyclopropene units, in good to excellent yields under mild reaction conditions.

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