As the combination of photothermal therapy (PTT) with immunotherapy provides an effective strategy in cancer treatment, a magnetic nanoparticle delivery system was constructed to load indocyanine green (ICG) and immunostimulator R837 hydrochloride (R837) for spatio-temporally PTT/immunotherapy synergism in cancer. This delivery system is composed of Fe₃O₄ magnetic nanoparticles (MPs) as the core to load ICG and polyethylene glycol polyphenols (DPA-PEG) as the coating layer to load R837, which formed R837 loaded polyphenols coating ICG loaded magnetic nanoparticles (MIRDs). After intravenous injection, the formed MIRDs resulted in long circulation, magnetic resonance imaging (MRI) guides, and magnetic targeting. Once targeting to the tumor, the MIRDs with the near-infrared (NIR) irradiation caused tumor ablation and resulted in tumor-associated antigens releasing to induce the body's immunological response, which was markedly improved it to attack the tumors with the R837 releasing from the outer DPA-PEG. In this case, the synergism of the PTT and immunotherapy inhibited tumor growth, metastasis and recurrence, which resulted in potent anticancer therapeutic effects with few side effect.

由于光热疗法（PTT）与免疫疗法的结合提供了一种有效的癌症治疗策略，因此构建了磁性纳米颗粒递送系统以装载吲哚菁绿（ICG）和免疫刺激剂R837盐酸盐（R837），以实现癌症时空PTT /免疫疗法的协同作用。该输送系统由Fe ₃ O _4组成磁性纳米颗粒（MPs）作为加载ICG的核心，聚乙二醇多酚（DPA-PEG）作为加载R837的涂层，形成形成R837的多酚涂层，涂覆ICG的磁性纳米颗粒（MIRD）。静脉注射后，形成的MIRD导致长循环，磁共振成像（MRI）引导和磁性靶向。一旦靶向肿瘤，用近红外（NIR）辐照的MIRD会引起肿瘤消融，并导致肿瘤相关抗原释放，从而诱导人体的免疫反应，从而显着改善了它的抵抗力，R837释放了R837来攻击肿瘤。外部DPA-PEG。在这种情况下，PTT和免疫疗法的协同作用抑制了肿瘤的生长，转移和复发，从而产生了有效的抗癌治疗作用，几乎没有副作用。