Rapid Fabrication of Self‐Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body,Advanced Functional Materials

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Rapid Fabrication of Self‐Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-06-18 , DOI: 10.1002/adfm.202002370
Sixiang Li _{1,

2} , Le Wang ₂ , Wenfu Zheng ₃ , Guang Yang ₁ , Xingyu Jiang ₂

Affiliation

Skin wounds on stretchable parts of the body including the elbows, knees, wrists, and nape usually undergo delayed and poor healing due to the interference of their frequent motion. Ordinary dressings that are not flexible enough face difficulty to promote wound healing due to the mismatching between the mechanics of the dressing materials and the wounds. In this study, an injectable, biocompatible, self‐healable, and conductive material poly(3,4‐ethylenedioxythiophene): poly(styrenesulfonate)/guar slime (PPGS) is developed for healing wounds with various kinds of movements. As a proof‐of‐principle assay, the healing effect of PPGS is explored on a skin wound model on the nape of rats that often experiences frequent movements. PPGS, which can be prepared within 1 min, successfully accelerates the healing of the wounds. The results suggest that PPGS has great potential in the fields of tissue engineering and biomedicine.

中文翻译：

快速制造自我修复，导电和可注射的凝胶，作为身体可拉伸部位伤口愈合的敷料

身体可拉伸部位（包括肘部，膝盖，腕部和项枕）上的皮肤伤口通常会由于频繁运动而受到干扰，因此愈合延迟且效果不佳。由于敷料材料的力学和伤口之间的不匹配，不够柔软的普通敷料面临难以促进伤口愈合的困难。在这项研究中，开发了一种可注射，生物相容，可自愈且导电的材料，聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）/瓜尔胶（PPGS），用于治疗各种动作的伤口。作为原理验证试验，在经常经历频繁运动的大鼠颈背上的皮肤伤口模型上探索了PPGS的愈合效果。可以在1分钟内制备的PPGS成功地促进了伤口的愈合。

更新日期：2020-08-03

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