Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine.,Organic Letters

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Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine.
Organic Letters ( IF 4.9 ) Pub Date : 2020-06-17 , DOI: 10.1021/acs.orglett.0c01905
Deliang Zhang ₁ , Tomohiro Iwai ₁ , Masaya Sawamura _{1,

2}

Affiliation

The polystyrene-cross-linking bisphosphine ligand PS-DPPBz was effective for the Ir-catalyzed reversible acceptorless dehydrogenation/hydrogenation of N-heterocycles. Notably, this protocol is applicable to the dehydrogenation of N-substituted indoline derivatives with various N-substituents with different electronic and steric natures. A reaction pathway involving oxidative addition of an N-adjacent C(sp³)–H bond to a bisphosphine-coordinated Ir(I) center is proposed for the dehydrogenation of N-substituted substrates.

中文翻译：

聚合物交联双膦使N取代和未取代的杂环进行Ir催化的可逆无受体脱氢/氢化。

聚苯乙烯交联双膦配体PS-DPPBz对于Ir催化的N-杂环可逆无受体脱氢/加氢有效。值得注意的是，该协议是适用于N的脱氢-取代有各种N-二氢吲哚衍生物-用不同的电子和空间性质的取代基。提出了一种反应途径，该途径涉及将N-相邻的C（sp ³）-H键与双膦配位的Ir（I）中心氧化加成，以使N-取代的底物脱氢。

更新日期：2020-07-02

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