Remarkable properties of hydrogels are compromised by failure to recover from damage, bringing their intended functions to an end. To address this, hydrogels can be functionalized with self-healing property to enable them to restore themselves after damage, thus, extending their lifetime. Herein, hydrogels were prepared by cross-linking acrylamide-modified β-chitin (Am-β-Chn) with alginate dialdehyde (ADA) to form Schiff base, showing IR characteristic peak at 1650 cm⁻¹, attributed to the stretching vibration of CN. The dynamic Schiff base and H-bond rendered the double crosslinked hydrogels self-healing as demonstrated by continuous step strain rheology. Characterization of the hydrogels revealed excellent biocompatibility, biodegradability, injectability and self-healing properties. Furthermore, the wound healing property of the hydrogels was investigated in vivo using zebrafish as a model system. Indirect application of Am-β-Chn/ADA hydrogel remarkably led to ~87% wound healing as compared to control which gave ~50%, suggesting that hydrogels are effective in accelerating wound healing. However, a clear understanding of the exact mechanism of its wound healing property remains to be investigated. To the best of our knowledge, this is the first innovation of developing novel double crosslinked Am-β-Chn/ADA hydrogels with both self-healing and accelerated wound healing properties, directly from marine-food wastes.

水凝胶的显着性能因无法从破坏中恢复而受损，从而终止了其预期功能。为了解决这个问题，水凝胶可以通过自我修复功能进行功能化，使其能够在受损后恢复自身，从而延长其使用寿命。本文中，通过将丙烯酰胺改性的β-几丁质（Am-β-Chn）与藻酸盐二醛（ADA）交联以形成席夫碱来制备水凝胶，该席夫碱在1650 cm ^-1处显示IR特征峰，这归因于C的拉伸振动N.动态席夫碱和H键使双交联水凝胶具有自愈性，如连续步进应变流变学所证明的那样。水凝胶的表征显示出优异的生物相容性，生物降解性，可注射性和自愈特性。此外，在体内研究了水凝胶的伤口愈合特性使用斑马鱼作为模型系统。与对照组相比，Am-β-Chn/ ADA水凝胶的间接应用显着导致〜87％的伤口愈合，而对照组的〜50％表现出水凝胶可有效促进伤口愈合。然而，对其伤口愈合特性的确切机理的清楚理解尚待研究。据我们所知，这是直接从海洋垃圾中开发出具有自我修复和加速伤口愈合特性的新型双交联Am-β-Chn/ ADA水凝胶的第一个创新。