A novel domino reaction from benzaldehydes and 2-acetylfuran/2-acetylthiophene with sodium sulfide was developed to synthesize a series of tetrahydrothiopyran (THTP) derivatives. The reaction proceeded well to construct a tetrahydrothiopyran ring and five new bonds in one step. A mechanism is proposed, involving a stepwise Aldol/double Michael addition/Aldol (AMMA) reaction cascade. In this transformation, sodium sulfide acts as a nucleophile and base. This method is characterized by transition-metal-free, commercially available starting materials and mild reaction conditions.

中文翻译：

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苯甲醛，2-乙酰呋喃/ 2-乙酰噻吩和硫化钠的四氢噻喃衍生物的多米诺合成策略。

建立了由苯甲醛和2-乙酰基呋喃/ 2-乙酰基噻吩与硫化钠形成的新型多米诺反应，以合成一系列四氢噻喃（THTP）衍生物。反应进行得很好，一步就可以构建一个四氢噻喃环和五个新的键。提出了一种涉及逐步Aldol /双迈克尔加成/ Aldol（AMMA）反应级联的机理。在该转化中，硫化钠充当亲核试剂和碱。该方法的特征在于无过渡金属的市售起始原料和温和的反应条件。