Membrane-Ion Interactions Modify the Lipid Flip-Flop Dynamics of Biological Membranes: A Molecular Dynamics Study.,The Journal of Physical Chemistry B

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Membrane-Ion Interactions Modify the Lipid Flip-Flop Dynamics of Biological Membranes: A Molecular Dynamics Study.
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2020-06-10 , DOI: 10.1021/acs.jpcb.0c04059
Miguel A Gonzalez ₁ , Fernando Bresme ₁

Affiliation

The asymmetric distribution of lipids in the cell membrane is maintained by protein transporters, and in the absence of proteins, by spontaneous flip-flop of lipids that involve the formation of transient pores in the membrane. The composition of the cell membranes influences the metabolism of the cell by modulating the function of transmembrane proteins, and flip-flop processes are therefore of key importance. Membranes are in direct contact with aqueous solutions, containing ions of different compositions that interact with the lipid head groups or cross the cell membrane through transmembrane channels. The impact of the ions on the lipid flip-flop rates is, however, an outstanding question. Here, we show that the flip-flop rate slows down significantly with the increasing valence of the cation, from minutes for monovalent cations (Na⁺, K⁺) to hours for divalent (Mg²⁺, Ca²⁺) or days for trivalent cations (Yb³⁺).

中文翻译：

膜离子相互作用修饰生物膜的脂质触发器动力学：分子动力学研究。

脂质在细胞膜中的不对称分布是由蛋白质转运蛋白维持的，在蛋白质不存在的情况下，是由脂质的自发翻转而引起的，脂质的自发翻转涉及在膜中形成瞬时孔。细胞膜的组成通过调节跨膜蛋白的功能来影响细胞的代谢，因此触发器过程至关重要。膜与水溶液直接接触，其中含有与脂质头基相互作用或通过跨膜通道穿过细胞膜的不同组成的离子。然而，离子对脂质翻转率的影响是一个悬而未决的问题。在这里，我们表明，随着阳离子价数的增加，触发器速率会显着降低，对于单价阳离子（Na⁺，K ⁺）表示二价（Mg 2 ⁺，Ca ²⁺）数小时或表示三价阳离子（Yb ³⁺）数天。

更新日期：2020-06-25

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