This review provides a report on cross-linking methods used for collagen modifications. Collagen materials have attracted significant academic interest due to its biological properties in native state. However, in many cases the mechanical properties and degradation rate should be tailored to especial biomedical and cosmetic applications.

In the proposed review paper, the structure, preparation, and properties of several collagen based materials have been discussed in general, and detailed examples of collagen cross-linking methods have been drawn from scientific literature and practical work. Both, physical and chemical methods of improvement of collagenous materials have been reviewed. In the review paper the cross-linking with glutaraldehyde, genipin, EDC-NHS, dialdehyde starch, chitosan, temperature, UV light and enzyme has been discussed. A critical comparison of currently available cross-linking methods has been shown.

这篇综述提供了用于胶原蛋白修饰的交联方法的报告。胶原材料由于其天然状态的生物学特性而引起了广泛的学术兴趣。但是，在许多情况下，应针对特殊的生物医学和化妆品应用调整机械性能和降解速率。

在拟议的综述文件中，已对几种胶原基材料的结构，制备和性能进行了一般性讨论，并从科学文献和实际工作中得出了胶原交联方法的详细实例。已经综述了改善胶原材料的物理和化学方法。在综述文件中，讨论了与戊二醛，京尼平，EDC-NHS，二醛淀粉，壳聚糖，温度，紫外线和酶的交联。已经显示了当前可用的交联方法的关键比较。