单铁阴离子fac- [Fe（CO）3I3]-及其有机铵盐：其制备，CO释放和细胞毒性,New Journal of Chemistry

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单铁阴离子fac- [Fe（CO）3I3]-及其有机铵盐：其制备，CO释放和细胞毒性
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-06-09 , DOI: 10.1039/d0nj01182g
Xiuqin Yang _{1,

2,

3,

4,

5} , Jing Jin _{4,

5,

6,

7} , Zhuming Guo _{5,

8,

9,

10} , Zhiyin Xiao _{1,

2,

3,

4,

5} , Naiwen Chen _{4,

5,

6,

7} , Xiujuan Jiang _{1,

2,

3,

4,

5} , Yi He _{4,

5,

6,

7} , Xiaoming Liu _{1,

2,

3,

4,

5}

Affiliation

在这项研究中，将含有相同的阴离子5克盐FAC - [铁^II（CO）₃我₃ ] ^-是通过反应制得的顺式的[Fe（CO） - ₄我₂ ]与有机胺，其质子化的形式，即，（ EtNH ₃⁺），（PrNH ₃⁺），（BuNH ₃⁺），（PentNH ₃⁺），和（ET ₂ NH ₂⁺），成为盐的阳离子1，2，3，4，和分别为5。这些铵盐可溶于水和极性有机溶剂（如DMSO和甲醇），并通过包括X射线单晶衍射在内的各种技术进行了表征。遵循一级动力学，这些盐在水和DMSO中均进行了溶剂分解，从而释放出CO。在DMSO中，这些盐的分解是通过一种比水溶液中自由基更简单的机理进行的，而没有自由基的参与，并且这些盐的CO释放速率几乎与疏水性呈线性关系（油/水分配系数的对数）P）的胺。水中的CO释放速率明显更快，并且除了进行溶剂分解外，这些阴离子还产生了碘自由基I˙。由于这些盐在水中的复杂分解，CO的释放以两阶段的方式进行。发现碘自由基至少部分负责这些盐在水中的细胞毒性。这表明所提出的阴离子具有在癌症治疗中的应用潜力。

"点击查看英文标题和摘要"

The monoiron anion fac-[Fe(CO)3I3]− and its organic aminium salts: their preparation, CO-release, and cytotoxicity

In this study, five salts containing the same anion fac-[Fe^II(CO)₃I₃]⁻ were prepared through the reaction of cis-[Fe(CO)₄I₂] with organic amines whose protonated forms, i.e., (EtNH₃⁺), (PrNH₃⁺), (BuNH₃⁺), (PentNH₃⁺), and (Et₂NH₂⁺), become the cations of the salts 1, 2, 3, 4, and 5, respectively. These aminium salts, which are soluble in water and polar organic solvents such as DMSO and methanol, were characterized by various techniques including X-ray single-crystal diffraction. These salts underwent solvolysis in both water and DMSO to release CO, following first-order kinetics. In DMSO, the decomposition of these salts proceeded via a significantly simpler mechanism without the involvement of radicals than that in water, and the CO-release rate of these salts was almost linearly related to the hydrophobicity (the logarithm of the oil/water partition coefficient P) of the amines. The CO-release rate was substantially faster in water and in addition to undergoing solvolysis, the anions generated an iodine radical, I˙. Due to the complicated decomposition of these salts in water, the CO-release proceeded in a two-stage manner. The iodine radical was found to be at least partly responsible for the cytotoxicity of these salts in water; this indicates that the proposed anion has potential for applications in cancer therapy.

更新日期：2020-06-29

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