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The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health.
Frontiers in Immunology ( IF 5.7 ) Pub Date : 2020-04-20 , DOI: 10.3389/fimmu.2020.00906
Bianca J Parker 1 , Pamela A Wearsch 1 , Alida C M Veloo 2 , Alex Rodriguez-Palacios 3, 4
Affiliation  

Alistipes is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at a low rate compared to other genus members of the Bacteroidetes phylum, which are highly relevant in dysbiosis and disease. According to the taxonomy database at The National Center for Biotechnology Information, the genus consists of 13 species: Alistipes finegoldii, Alistipes putredinis, Alistipes onderdonkii, Alistipes shahii, Alistipes indistinctus, Alistipes senegalensis, Alistipes timonensis, Alistipes obesi, Alistipes ihumii, Alistipes inops, Alistipes megaguti, Alistipes provencensis, and Alistipes massiliensis. Alistipes communis and A. dispar, and the subspecies A. Onderdonkii subspecies vulgaris (vs. onderdonkii subsp.) are the newest strains featured outside that list. Although typically isolated from the human gut microbiome various species of this genus have been isolated from patients suffering from appendicitis, and abdominal and rectal abscess. It is possible that as Alistipes spp. emerge, their identification in clinical samples may be underrepresented as novel MS-TOF methods may not be fully capable to discriminate distinct species as separate since it will require the upgrading of MS-TOF identification databases. In terms of pathogenicity, there is contrasting evidence indicating that Alistipes may have protective effects against some diseases, including liver fibrosis, colitis, cancer immunotherapy, and cardiovascular disease. In contrast, other studies indicate Alistipes is pathogenic in colorectal cancer and is associated with mental signs of depression. Gut dysbiosis seems to play a role in determining the compositional abundance of Alistipes in the feces (e.g., in non-alcoholic steatohepatitis, hepatic encephalopathy, and liver fibrosis). Since Alistipes is a relatively recent sub-branch genus of the Bacteroidetes phylum, and since Bacteroidetes are commonly associated with chronic intestinal inflammation, this narrative review illustrates emerging immunological and mechanistic implications by which Alistipes spp. correlate with human health.



中文翻译:

Alistipes类:肠道细菌,对炎症,癌症和心理健康具有新的含义。

阿利斯佩斯 是主要从医学临床样本中分离出的相对较新的细菌属,尽管与其他细菌属相比发病率较低 拟杆菌属门,与营养不良和疾病高度相关。根据国家生物技术信息中心的分类数据库,该属包括13种:Alistipes finegoldii,Alistipes putredinis,Alistipes onderdonkii,Alistipes shahii,Alistipes indistinctus,Alistipes senegalensis,Alistipes timonensis,Alistipes obesi,Alistipes ihumii,Alistipes inops,Alistipes megaguti马斯提利斯。阿利斯皮斯A.dispar,以及亚种 A.翁德基基 寻常亚种(vs. Onderdonkii(subsp。)是该列表以外的最新菌株。尽管通常从人类肠道微生物组中分离出来,但是从患有阑尾炎,腹部和直肠脓肿的患者中分离出了该属的各种物种。作为阿利斯佩斯spp。出现后,由于新的MS-TOF方法可能无法完全区分不同物种,因此它们在临床样品中的鉴定可能不足,因为这将需要升级MS-TOF鉴定数据库。在致病性方面,有相反的证据表明阿利斯佩斯可能对某些疾病(包括肝纤维化,结肠炎,癌症免疫疗法和心血管疾病)具有保护作用。相反,其他研究表明阿利斯佩斯在大肠癌中具有致病性,并与精神抑郁症有关。肠道营养不良似乎在确定食蟹猴的成分丰度中起作用阿利斯佩斯 在粪便中例如(非酒精性脂肪性肝炎,肝性脑病和肝纤维化)。以来阿利斯佩斯 是相对较新的支行属 拟杆菌属 门,从 拟杆菌属 通常与慢性肠道炎症相关,该叙述性综述说明了新出现的免疫学和机械学意义, 阿利斯佩斯spp。与人类健康相关。

更新日期:2020-04-20
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