Understanding the inhibitory mechanism of cryoprotective agent on ice growth is essential for preventing the cryoinjury of vivo biological tissue and for the bioactive protection of protein medicine in cryopreservation processes. The crystallization growth process of (0 2 0) crystal face of orthorhombic ice in l-lysine hydrochloride aqueous solutions was researched by molecular dynamic. The results indicated that l-lysine ion has a competitive adsorption on the lattice sites of ice interface with water molecule. The binding carboxyl (COO⁻) and flexible l-lysine chain can disrupt the periodic continuous growth of ice. The free l-lysine ion and chlorine anion (Cl⁻) inhibit the diffusion of water molecules which makes ice crystals difficult to grow. This final results proved that l-lysine ion can inhibit ice crystal growth in both aqueous and crystalline phases.

理解冷冻保护剂对冰生长的抑制机制对于防止体内生物组织的冷冻损伤和冷冻保存过程中蛋白质药物的生物活性保护至关重要。通过分子动力学研究了正交晶冰在（0 2 0）晶面在1-赖氨酸盐酸盐水溶液中的结晶生长过程。结果表明，1-赖氨酸离子在冰与水分子界面的晶格位上具有竞争性吸附。结合的羧基（COO ^- ）和灵活的升赖氨酸链可以破坏冰的周期持续增长。自由升赖氨酸离子和氯阴离子（氯^-）抑制水分子的扩散，使冰晶难以生长。该最终结果证明1-赖氨酸离子可以抑制冰相在水相和结晶相中的生长。