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Preventative and therapeutic effects of fennel (Foeniculum vulgare) seed extracts against necrotizing enterocolitis.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-06-08 , DOI: 10.1111/jfbc.13284
Halil Ibrahim Yakut 1 , Ece Koyuncu 2 , Ufuk Cakir 3 , Cuneyt Tayman 3 , İsmail Koyuncu 4 , Tugba Taskin Turkmenoglu 5 , Esra Cakir 6 , Ahmet Ozyazici 2 , Seda Aydogan 2 , Aysegul Zenciroglu 2
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-06-08 , DOI: 10.1111/jfbc.13284
Halil Ibrahim Yakut 1 , Ece Koyuncu 2 , Ufuk Cakir 3 , Cuneyt Tayman 3 , İsmail Koyuncu 4 , Tugba Taskin Turkmenoglu 5 , Esra Cakir 6 , Ahmet Ozyazici 2 , Seda Aydogan 2 , Aysegul Zenciroglu 2
Affiliation
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We aimed to understand the efficacy of fennel (Foeniculum vulgare: FV) extract in an experimental necrotizing enterocolitis (NEC) model. Forty‐two rat pups were divided into three groups as NEC, NEC treated with fennel extract, and control. At the end of the experiment, tissue samples were taken from the proximal colon and ileum for biochemical and immuno‐histological studies including hematoxylin‐eosin and Caspase‐3‐8‐9 immunohistochemical staining. Bowel damage and apoptosis were found to be less in the NEC + FV group. Oxidant stress, caspase 3, TNF‐α, and IL‐6 levels were considerably decreased in the NEC + FV group. Antioxidants were significantly higher in the NEC + FV group more than in the NEC group. Moreover, protein, DNA damage, and lipid peroxidation were found to be decreased in the NEC + FV group compared to the NEC group.
中文翻译:
茴香籽提取物对坏死性小肠结肠炎的预防和治疗作用。
我们的目的是了解茴香(Foeniculum vulgare:FV)提取物在实验性坏死性小肠结肠炎(NEC)模型中。将42只大鼠幼崽分为三组,即NEC,茴香提取物处理的NEC和对照组。实验结束时,从结肠和回肠近端采集组织样本进行生化和免疫组织学研究,包括苏木精-伊红和Caspase-3-8-9免疫组化染色。发现NEC + FV组的肠损伤和细胞凋亡较少。NEC + FV组的氧化应激,caspase 3,TNF-α和IL-6水平显着降低。NEC + FV组的抗氧化剂明显高于NEC组。此外,与NEC组相比,NEC + FV组的蛋白质,DNA损伤和脂质过氧化作用降低。
更新日期:2020-06-08
中文翻译:
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茴香籽提取物对坏死性小肠结肠炎的预防和治疗作用。
我们的目的是了解茴香(Foeniculum vulgare:FV)提取物在实验性坏死性小肠结肠炎(NEC)模型中。将42只大鼠幼崽分为三组,即NEC,茴香提取物处理的NEC和对照组。实验结束时,从结肠和回肠近端采集组织样本进行生化和免疫组织学研究,包括苏木精-伊红和Caspase-3-8-9免疫组化染色。发现NEC + FV组的肠损伤和细胞凋亡较少。NEC + FV组的氧化应激,caspase 3,TNF-α和IL-6水平显着降低。NEC + FV组的抗氧化剂明显高于NEC组。此外,与NEC组相比,NEC + FV组的蛋白质,DNA损伤和脂质过氧化作用降低。