Manganese-catalyzed regioselective C–H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C–H functionalization, this protocol does not require a Grignard reagent base and employs a simple and inexpensive MnBr₂ as a catalyst. This method tolerates diverse functionalities, including fluoro, chloro, bromo, iodo, alkenyl, alkynyl, pyrrolyl, and carbazolyl groups. The alkylation proceeds through a single-electron transfer pathway comprising reversible C–H manganesation and involving an alkyl radical intermediate.

中文翻译：

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MnBr2-催化的吲哚和苯并[h]喹啉直接和位点选择性烷基化。

据报道，锰催化了吲哚和苯并[ h ]喹啉与多种未活化的烷基碘的区域选择性C–H烷基化反应。与其他Mn催化的C–H功能化不同，该方案不需要格氏试剂碱，而是使用简单且便宜的MnBr ₂作为催化剂。该方法耐受多种功能，包括氟，氯，溴，碘，烯基，炔基，吡咯基和咔唑基。烷基化通过单电子转移途径进行，该途径包括可逆的C–H锰离子化并涉及烷基自由基中间体。