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Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases.
ACS Nano ( IF 15.8 ) Pub Date : 2020-06-03 , DOI: 10.1021/acsnano.9b09726 Hyunsik Choi 1 , Seong Hwi Cho 1 , Sei Kwang Hahn 1
ACS Nano ( IF 15.8 ) Pub Date : 2020-06-03 , DOI: 10.1021/acsnano.9b09726 Hyunsik Choi 1 , Seong Hwi Cho 1 , Sei Kwang Hahn 1
Affiliation
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Intravesical therapeutic delivery has been extensively investigated for various bladder diseases such as bladder cancer, overactive bladder, urinary incontinence, and interstitial cystitis. However, conventional drug carriers have a low therapeutic delivery efficiency because of the passive diffusion of drug molecules in a bladder and the rapid clearance by periodic urination. Here, we report biocompatible and bioavailable enzyme-powered polymer nanomotors which can deeply penetrate into a mucosa layer of the bladder wall and remain for a long-term period in the bladder. The successful fabrication of nanomotors was confirmed by high-resolution transmission electron microscopy, energy-dispersive X-ray mapping, zeta-potential analysis, Fourier transform infrared spectroscopy, and urease activity and nanomotor trajectory analyses. After injection into the bladder, urease-immobilized nanomotors became active, moving around in the bladder by converting urea into carbon dioxide and ammonia. The nanomotors resulted in the facilitated penetration to the mucosa layer of the bladder wall and the prolonged retention in the bladder even after repeated urination. The enhanced penetration and retention of the nanomotors as a drug delivery carrier in the bladder would be successfully harnessed for treating a variety of bladder diseases.
中文翻译：
脲酶动力的聚多巴胺纳米马达用于膀胱疾病的膀胱内治疗。
对于各种膀胱疾病，例如膀胱癌，膀胱过度活动症，尿失禁和间质性膀胱炎，已经进行了膀胱内治疗递送的广泛研究。然而，由于药物分子在膀胱中的被动扩散以及通过定期排尿的快速清除，常规药物载体的治疗递送效率较低。在这里，我们报告生物相容性和生物利用酶驱动的聚合物纳米电机，可以深入渗透到膀胱壁的粘膜层，并在膀胱中长期保留。高分辨率透射电子显微镜，能量色散X射线绘图，ζ电位分析，傅立叶变换红外光谱以及脲酶活性和纳米马达运动轨迹分析证实了纳米马达的成功制造。注入膀胱后，固定有脲酶的纳米马达开始运转，通过将尿素转化为二氧化碳和氨在膀胱中移动。纳米马达即使在反复排尿后，也易于渗透到膀胱壁的粘膜层，并且在膀胱中的保留时间更长。纳米马达作为药物递送载体在膀胱中的增强的渗透和保留将被成功地用于治疗多种膀胱疾病。
更新日期：2020-06-23
中文翻译：
脲酶动力的聚多巴胺纳米马达用于膀胱疾病的膀胱内治疗。
对于各种膀胱疾病，例如膀胱癌，膀胱过度活动症，尿失禁和间质性膀胱炎，已经进行了膀胱内治疗递送的广泛研究。然而，由于药物分子在膀胱中的被动扩散以及通过定期排尿的快速清除，常规药物载体的治疗递送效率较低。在这里，我们报告生物相容性和生物利用酶驱动的聚合物纳米电机，可以深入渗透到膀胱壁的粘膜层，并在膀胱中长期保留。高分辨率透射电子显微镜，能量色散X射线绘图，ζ电位分析，傅立叶变换红外光谱以及脲酶活性和纳米马达运动轨迹分析证实了纳米马达的成功制造。注入膀胱后，固定有脲酶的纳米马达开始运转，通过将尿素转化为二氧化碳和氨在膀胱中移动。纳米马达即使在反复排尿后，也易于渗透到膀胱壁的粘膜层，并且在膀胱中的保留时间更长。纳米马达作为药物递送载体在膀胱中的增强的渗透和保留将被成功地用于治疗多种膀胱疾病。
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