In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecules was ascertained by biofilm inhibition study against Escherichia coli and Bacillus subtilis. The results revealed that two of the compounds were rather active inhibitors of these two pathogenic bacterial strains. According to the hemolytic study, most of the new molecules are mildly cytotoxic and hence might be used as safe antibacterial agents.

中文翻译：

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N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl) 苯磺酰胺的细菌生物膜抑制、溶血活性和构效关系

在这项工作中，制造了在其框架中结合磺酰胺和苯二恶烷片段的新型抗菌化合物。磺酰胺衍生物的结构通过 IR、1H NMR、13C NMR 和 EI-MS 光谱技术确定。通过对大肠杆菌和枯草芽孢杆菌的生物膜抑制研究，确定了这些分子的抗菌潜力。结果表明，其中两种化合物是这两种病原菌株的活性抑制剂。根据溶血研究，大多数新分子具有轻微的细胞毒性，因此可用作安全的抗菌剂。