Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing.,ACS Applied Materials & Interfaces

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Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-06-01 , DOI: 10.1021/acsami.0c00782
Shuai Liu _{1,

2,

3} , Xin Liu ₂ , Yanhan Ren ₄ , Penghui Wang ₂ , Yajie Pu ₂ , Rong Yang ₂ , Xiaoxue Wang ₂ , Xiaoyan Tan ₂ , Zhiwen Ye ₁ , Victor Maurizot ₅ , Bo Chi _{2,

3}

Affiliation

Physicians have long been calling for an inherent antimicrobial wound dressing, which will be a great progress for treating complicated infections. Here, we report a novel bioadhesive hydrogel with inherent antibacterial properties prepared by mixing modified hyaluronic acid (HA) and ε-polylysine (EPL). This hydrogel can effectively kill Gram (+) and (−) bacteria for its high positive charge density on the surface. The sol–gel transition occurs within seconds via horseradish peroxidase enzymatic cross-linking and Schiff base reaction, which also allows the hydrogel to recover completely from destruction quickly within 5 min. In an infected rat wound model, histological studies indicated that the hydrogels effectively killed bacteria on the surface of wounds and accelerated wound healing. Histological analysis indicated that the thickness of the newborn skin, the density of the newborn microvascular, granulation tissue, and the collagen of rats treated with hydrogel dressings were twice as high as those treated by commercial fibrin glue. These results indicate that the HA/EPL hydrogel has great potential as an antibacterial wound dressing for future clinical applications.

中文翻译：

贻贝启发的具有自修复作用和抗菌特性的双交联透明质酸/ε-聚赖氨酸水凝胶，可用于伤口愈合。

长期以来，内科医生一直在呼吁使用固有的抗菌伤口敷料，这将在治疗复杂感染方面取得重大进展。在这里，我们报告了一种新型生物粘合水凝胶，具有固有的抗菌特性，可通过混合改性透明质酸（HA）和ε-聚赖氨酸（EPL）制备。这种水凝胶可有效杀死革兰氏（+）和（-）细菌，因为其表面具有很高的正电荷密度。通过辣根过氧化物酶的酶促交联和席夫碱反应，可在几秒钟内发生溶胶-凝胶转变，这也使水凝胶可在5分钟内迅速从破坏中完全恢复。在受感染的大鼠伤口模型中，组织学研究表明，水凝胶可有效杀死伤口表面的细菌并加速伤口愈合。组织学分析表明，用水凝胶敷料处理的大鼠新生皮肤的厚度，新生微血管，肉芽组织的密度和胶原蛋白的含量是市售纤维蛋白胶处理的两倍。这些结果表明，HA / EPL水凝胶作为抗菌伤口敷料具有巨大的潜力，可用于未来的临床应用。

更新日期：2020-06-24

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