户外栽培的皇家太阳药用蘑菇巴西姬松茸KA21（姬松茸）减少抗癌药物的副作用。,International Journal of Medicinal Mushrooms

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户外栽培的皇家太阳药用蘑菇巴西姬松茸KA21（姬松茸）减少抗癌药物的副作用。
International Journal of Medicinal Mushrooms ( IF 1.4 ) Pub Date : 2020-01-01 , DOI: 10.1615/intjmedmushrooms.2019033173
Katsuya Tajima ₁ , Hoichi Amano ₂ , Akitomo Motoi ₃ , Daisuke Yamanaka ₄ , Ken-Ichi Ishibashi ₄ , Yoshiyuki Adachi ₄ , Naohito Ohno ₅

Affiliation

我们调查了户外栽培的巴西姬松茸（KA21）是否可以减少由抗癌药物5-氟尿嘧啶（5-FU）引起的副作用。通过每天口服给药5天来分析小鼠中5-FU的不良反应。白细胞减少，腹泻，体重减轻，厌食，肾脏损伤，胃肠道损伤和脱发被评估为副作用。我们确定是否通过摄入室外栽培的巴西巴西曲霉降低了这些副作用。接受室外培养的巴西曲霉的小鼠的副作用减少，但接受室内培养的巴西曲霉的小鼠的副作用没有降低。这些结果表明，室外培养的巴西巴西曲霉有益于减少抗癌药的副作用，因此可能有助于改善癌症患者的生活质量。此外，由于据报道抗氧化剂有助于抑制抗癌药物的副作用，因此确定了不同蘑菇的抗氧化活性。在所有测试过的蘑菇中，户外栽培的巴西巴西蘑菇的抗氧化活性最高。这些发现清楚地表明，巴西曲霉的培养条件对于抑制抗癌药的副作用很重要。强大的抗氧化剂活性可能是介导这种药理活性的机制之一。测定了不同蘑菇的抗氧化活性。在所有测试过的蘑菇中，户外栽培的巴西巴西蘑菇的抗氧化活性最高。这些发现清楚地表明，巴西曲霉的培养条件对于抑制抗癌药的副作用很重要。强大的抗氧化剂活性可能是介导这种药理活性的机制之一。测定了不同蘑菇的抗氧化活性。在所有测试过的蘑菇中，户外栽培的巴西巴西蘑菇的抗氧化活性最高。这些发现清楚地表明，巴西曲霉的培养条件对于抑制抗癌药的副作用很重要。强大的抗氧化剂活性可能是介导这种药理活性的机制之一。

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Outdoor-Cultivated Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Reduces Anticancer Medicine Side Effects.

We investigated whether outdoor-cultivated Agaricus brasiliensis (KA21) could reduce the side effects caused by the anticancer medicine 5-fluorouracil (5-FU). The adverse effects of 5-FU were analyzed in mice by orally administering the drug every day for 5 days. Leukopenia, diarrhea, body weight loss, anorexia, kidney injury, gastrointestinal tract injury, and hair loss were evaluated as side effects. We determined whether these side effects were reduced by the intake of outdoor-cultivated A. brasiliensis. The side effects were reduced in mice receiving the outdoor-cultivated A. brasiliensis but not in those receiving the indoor-cultivated A. brasiliensis. These results suggest that outdoor-cultivated A. brasiliensis is beneficial in reducing the side effects of the anticancer medicine and might, therefore, be useful in improving the quality of life of patients with cancer. Furthermore, because antioxidants have been reported to contribute to the suppression of the side effects of anticancer medicines, the antioxidant activities of different mushrooms were determined. The antioxidant activity of the outdoor-cultivated A. brasiliensis was the highest among all the tested mushrooms. These findings make it clear that the cultivation conditions of A. brasiliensis are important in suppressing the side effects of anticancer medicines. Strong antioxidant activity might be one of the mechanisms through which this pharmacological activity is mediated.

更新日期：2020-01-01

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