Objective: 

The incidence of melanoma is increasing. Other than limiting UV exposure, few factors prevent or reduce the risk of melanoma. The aim of this study is to evaluate the relationship between vitamin D intake and melanoma risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial.

Methods: 

A secondary data analysis was performed on PLCO data. More than 1,300 participants developed melanoma.

Results: 

Melanoma risk may be increased among men within the highest quartile of vitamin D intake (HR 1.27, 95% CI 0.99, 1.61). Women in the highest quartile of vitamin D intake had a decreased risk of invasive melanoma (HR 0.63, 95% CI 0.41, 0.96). Higher education and being white corresponded with deeper tumors (P < .001).

Conclusion: 

High reported vitamin D intake resulted in an increased risk of melanoma among men. Vitamin D intake yielded a protective effect against invasive melanoma in women.

中文翻译：

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PLCO癌症筛查试验患者的维生素D，黑色素瘤风险和肿瘤厚度。

目的： 

黑色素瘤的发病率正在增加。除了限制紫外线照射外，很少有因素可以预防或减少黑色素瘤的风险。这项研究的目的是评估前列腺癌，肺癌，结直肠癌和卵巢癌（PLCO）癌症筛查试验中维生素D摄入量与黑色素瘤风险之间的关系。

方法： 

对PLCO数据进行了二次数据分析。1300多名参与者患了黑色素瘤。

结果： 

在维生素D摄入量最高的四分位数内的男性中，黑色素瘤的风险可能会增加（HR 1.27，95％CI 0.99，1.61）。维生素D摄入量最高的四分之一女性的浸润性 黑色素瘤风险降低（HR 0.63，95％CI 0.41，0.96）。受过高等教育和变白的人与更深的肿瘤相对应（P <.001）。

结论： 

维生素D摄入量高导致男性中黑色素瘤的风险增加。摄取维生素D对女性的侵袭性 黑色素瘤具有保护作用。