Phenoxy herbicides are widely applied in agricultural weeding. The determination of herbicides is important in environmental protection, agricultural production, food safety, and public health. In this study, a facile and efficient analytical method was proposed for the trace detection of phenoxy herbicides in soil, cucumber, and tap water samples by coupling pipette tip solid phase extraction (PT-SPE) with high performance liquid chromatography. UiO-66-funtionalized cotton (Cotton@UiO-66) was packed into pipette-tip as sorbent to fabricate extraction device. The modification of UiO-66 on cotton fiber was confirmed using scanning electron microscope, Fourier transform infrared spectroscopy, and X-ray diffraction. The main factors affecting the adsorption of Cotton@UiO-66 for four phenoxy herbicides were evaluated by response surface methodology in detail. Under optimized conditions, Cotton@UiO-66 displayed excellent properties in the extraction of phenoxy herbicides with good peak shape. Linear ranges of 4-chlorophenoxyacetic acid, dicamba, 2,4-dichlorophenoxyacetic acid, and 2-(2,4-dichlorophenoxy) propionic acid were 1.4–72 μg/L, 5.6–280 μg/L, 2.8–140 μg/L and 3.2–160 μg/L (RSDs < 6.3%), respectively. The recoveries were between 83.3 and 106.8% with RSDs <6.7%, with detection limits ranging from 0.1 μg/L to 0.3 μg/L. The results show that Cotton@UiO-66 in PT-SPE is an effective method for monitoring phenoxy herbicides in complex samples.

苯氧基除草剂广泛用于农业除草。除草剂的测定对环境保护，农业生产，食品安全和公共卫生至关重要。在这项研究中，提出了一种简便高效的分析方法，通过将移液管尖端固相萃取（PT-SPE）与高效液相色谱耦合，可以痕量检测土壤，黄瓜和自来水样品中的苯氧基除草剂。将UiO-66官能化棉（Cotton @ UiO-66）包装到移液器吸头中作为吸附剂以制造提取装置。使用扫描电子显微镜，傅立叶变换红外光谱和X射线衍射证实了UiO-66在棉纤维上的改性。通过响应面法详细评估了影响Cotton @ UiO-66吸附四种苯氧基除草剂的主要因素。在最佳条件下，Cotton @ UiO-66在萃取具有良好峰形的苯氧基除草剂中显示出优异的性能。4-氯苯氧基乙酸，麦草畏，2,4-二氯苯氧基乙酸和2-（2,4-二氯苯氧基）丙酸的线性范围分别为1.4-72μg/ L，5.6-280μg/ L，2.8-140μg/ L和3.2–160μg/ L（RSDs <6.3％）。回收率在83.3至106.8％之间，RSDs ＜6.7％，检出限为0.1μg/ L至0.3μg/ L。结果表明，PT-SPE中的Cotton @ UiO-66是监测复杂样品中苯氧基除草剂的有效方法。Cotton @ UiO-66在具有良好峰形的苯氧基除草剂的提取中显示出优异的性能。4-氯苯氧基乙酸，麦草畏，2,4-二氯苯氧基乙酸和2-（2,4-二氯苯氧基）丙酸的线性范围分别为1.4-72μg/ L，5.6-280μg/ L，2.8-140μg/ L和3.2–160μg/ L（RSDs <6.3％）。回收率在83.3至106.8％之间，RSDs ＜6.7％，检出限为0.1μg/ L至0.3μg/ L。结果表明，PT-SPE中的Cotton @ UiO-66是监测复杂样品中苯氧基除草剂的有效方法。Cotton @ UiO-66在具有良好峰形的苯氧基除草剂的提取中显示出优异的性能。4-氯苯氧基乙酸，麦草畏，2,4-二氯苯氧基乙酸和2-（2,4-二氯苯氧基）丙酸的线性范围分别为1.4-72μg/ L，5.6-280μg/ L，2.8-140μg/ L和3.2–160μg/ L（RSDs <6.3％）。回收率在83.3至106.8％之间，RSDs ＜6.7％，检出限为0.1μg/ L至0.3μg/ L。结果表明，PT-SPE中的Cotton @ UiO-66是监测复杂样品中苯氧基除草剂的有效方法。RSDs <6.7％时，检测限为3和106.8％，检测限范围为0.1μg/ L至0.3μg/ L。结果表明，PT-SPE中的Cotton @ UiO-66是监测复杂样品中苯氧基除草剂的有效方法。RSDs <6.7％时，检测限为3和106.8％，检测限范围为0.1μg/ L至0.3μg/ L。结果表明，PT-SPE中的Cotton @ UiO-66是监测复杂样品中苯氧基除草剂的有效方法。