坚固的聚（N-丙烯酰基-2-甘氨酸）基海绵，可快速止血。,Biomaterials Science

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坚固的聚（N-丙烯酰基-2-甘氨酸）基海绵，可快速止血。
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-29 , DOI: 10.1039/d0bm00770f
Xinyu Chen ₁ , Chunyan Cui , Yang Liu , Chuanchuan Fan , Meng Xiao , Dongfei Zhang , Ziyang Xu , Yuan Li , Jianhai Yang , Wenguang Liu

Affiliation

可用于治疗动脉出血和不可压缩的出血的止血海绵的开发仍然是一个挑战。在这项工作中，我们建议通过氢键加强和热引发聚合中的原位气泡扩展策略来制造坚固的止血海绵。增稠剂羧甲基纤维素（CMC）被掺入氢键N中-丙烯酰基-2-甘氨酸（ACG）单体和引发剂，涡旋在粘性液体中产生气泡。加热引发快速聚合，同时有助于气泡膨胀，从而导致气泡在整个网络中固定并形成多孔水凝胶。由于PACG的氢键相互作用，发泡水凝胶的进一步冻干导致最终产生具有强大抗压强度的PACG / CMC海绵。显示PACG / CMC海绵在体外具有可调的液体吸收能力止血能力，更好的血液相容性和细胞相容性。在大鼠肝损伤模型和股动脉损伤模型中，与纱布和市售明胶海绵相比，PACG / CMC海绵可以显着减少出血时间和失血，因为它具有较高的吸血能力和有效的凝血因子浓度。这种PACG海绵作为紧急情况下的止血剂具有广阔的前景。

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A robust poly(N-acryloyl-2-glycine)-based sponge for rapid hemostasis.

The development of a hemostatic sponge that can be used for treating both arterial hemorrhage and non-compressible bleeding remains a challenge. In this work, we propose the fabrication of a robust hemostatic sponge by a hydrogen bond strengthening and in situ bubble expanding strategy in thermo-initiation polymerization. A thickening agent, carboxymethyl cellulose (CMC), is incorporated into a hydrogen bonding N-acryloyl-2-glycine (ACG) monomer and an initiator, and vortexing generates air bubbles in the viscous liquid. Heating initiates fast polymerization, and meanwhile aids in expanding of bubbles, which results in the fixation of bubbles throughout the network, and the formation of porous hydrogels. Further lyophilization of the foaming hydrogels leads to the final generation of PACG/CMC sponges with robust compressive strengths due to the hydrogen bonding interactions of PACG. PACG/CMC sponges are shown to demonstrate a tunable liquid absorption ability, in vitro hemostatic ability, better hemocompatibility and cytocompatibility. In a rat liver injury model and a femoral artery injury model, the PACG/CMC sponge can significantly reduce the bleeding time and blood loss compared with gauze and commercial gelatin sponge because of the high blood absorption ability and effective concentration of blood coagulation factors. This PACG sponge holds promising potential as a hemostatic agent applicable in an emergency.

更新日期：2020-06-30

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