SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides.,Organic Letters

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SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides.
Organic Letters ( IF 4.9 ) Pub Date : 2020-05-27 , DOI: 10.1021/acs.orglett.0c01397
Subham Mahapatra ₁ , Cristian P Woroch ₂ , Todd W Butler ₁ , Sabrina N Carneiro ₂ , Sabrina C Kwan ₂ , Samuel R Khasnavis ₂ , Junha Gu ₂ , Jason K Dutra ₁ , Beth C Vetelino ₁ , Justin Bellenger ₁ , Christopher W Am Ende ₁ , Nicholas D Ball ₂

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A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

中文翻译：

用Ca（NTf2）2进行SuFEx活化：从S（VI）氟化物中获取磺酰胺，氨基磺酸盐和磺酰胺的统一策略。

描述了用三氟甲磺酸钙和DABCO活化胺磺酰氟，氟硫酸盐和磺酰氟的方法，用于胺与SuFEx。在室温和温和条件下，将反应物应用于各种不同的磺酰胺，氨基磺酸盐和磺酰胺。此外，我们强调了这种向平行药物化学的转化，以生成各种基于氮的S（VI）化合物。

更新日期：2020-05-27

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