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Crotonpenoids A and B, Two Highly Modified Clerodane Diterpenoids with a Tricyclo[7.2.1.02,7]dodecane Core from Croton yanhuii: Isolation, Structural Elucidation, and Biomimetic Semisynthesis.
Organic Letters ( IF 4.9 ) Pub Date : 2020-05-26 , DOI: 10.1021/acs.orglett.0c01443
Wei Li 1 , Rui-Min Wang 1 , Yue-Hua Pan 1 , Ying-Yuan Zhao 1 , Fang-Yu Yuan 1 , Dong Huang 1 , Gui-Hua Tang 1 , Hui-Chang Bi 1 , Sheng Yin 1
Affiliation  

Crotonpenoids A (1) and B (2), two highly modified clerodane diterpenoids featuring a new 10-(butan-2-yl)-1,6,12-trimethyltricyclo[7.2.1.02,7]dodecane skeleton, were isolated from the leaves and twigs of Croton yanhuii. Their structures including the absolute configurations were determined by spectroscopic analysis, single-crystal X-ray diffraction, and biomimetic semisynthesis. Compounds 1 and 2 exhibited an agonistic effect on pregnane X receptor at 10 μM.

中文翻译:

巴豆类固醇A和B,两种高度修饰的具有Croton yanhuii三环[7.2.1.02,7]十二烷核的环戊烷二萜类化合物:分离,结构阐明和仿生半合成。

从中分离出具有两个新的10-(butan-2-yl)-1,6,12-trimethyltricyclo [7.2.1.0 2,7 ]十二烷骨架的两个高度改性的clerodane二萜类化合物Crotonpenoids A(1)和B(2)。巴豆艳辉的叶子和树枝。通过光谱分析,单晶X射线衍射和仿生半合成确定了它们的结构,包括绝对构型。化合物12对10μM的孕烷X受体表现出激动作用。
更新日期:2020-05-26
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