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Ferrocene Functionalized Upconversion Nanoparticle Nanosystem with Efficient Near-Infrared-Light-Promoted Fenton-Like Reaction for Tumor Growth Suppression.
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-05-24 , DOI: 10.1021/acs.inorgchem.0c01073 Jimin Zhou , Xiangfeng Zhu , Qianya Cheng , Yuxuan Wang 1 , Ruiqi Wang , Xingwen Cheng 2 , Jiajia Xu 2 , Kuntang Liu , Lin Li 2 , Xueming Li , Mingfang He , Jian Wang 3 , Heng Xu , Su Jing , Ling Huang 2
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-05-24 , DOI: 10.1021/acs.inorgchem.0c01073 Jimin Zhou , Xiangfeng Zhu , Qianya Cheng , Yuxuan Wang 1 , Ruiqi Wang , Xingwen Cheng 2 , Jiajia Xu 2 , Kuntang Liu , Lin Li 2 , Xueming Li , Mingfang He , Jian Wang 3 , Heng Xu , Su Jing , Ling Huang 2
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By taking advantage of the efficient Förster resonance energy transfer (FRET) between near-infrared (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (Fc), a series of Fc-UCNPs was designed by functionalizing NaYF4:Yb,Tm nanoparticles with Fc1–Fc5via surface-coordination chemistry. Fc-UCNP-Lipo nanosystems were then constructed by encapsulating Fc-UCNP inside liposomes for efficient delivery. Fc-UCNP can effectively release ·OH via a NIR-promoted Fenton-like reaction. In vitro and in vivo studies of Fc1-UCNP-Lipo confirmed the preferential accumulation in a tumor site followed by an enhanced uptake of cancer cells. After cellular internalization, the released Fc1-UCNP can effectively promote ·OH generation for tumor growth suppression. Such a Fc1-UCNP-Lipo nanosystem exhibits advantages such as easy fabrication, low drug dosage, and no ferrous ion release.
中文翻译：
二茂铁功能化的上转换纳米粒子纳米系统具有有效的近红外光促进芬顿样反应抑制肿瘤生长。
通过利用近红外（NIR）响应的镧系元素掺杂的上转换纳米粒子（UCNP）和Fenton试剂二茂铁基化合物（Fc）之间的有效Förster共振能量转移（FRET），通过功能化NaYF设计了一系列Fc -UCNP 4：通过表面配位化学方法，具有Fc1 - Fc5的Yb，Tm纳米颗粒。然后通过将Fc -UCNP封装在脂质体内以有效递送来构建Fc -UCNP-Lipo纳米系统。Fc -UCNP可通过NIR促进的Fenton样反应有效释放·OH 。体外和体内研究FC1 -UCNP-前列证实在肿瘤部位，随后癌细胞的增强吸收的优先积累。细胞内化后，释放的Fc1- UCNP可有效促进·OH生成，从而抑制肿瘤生长。这样的Fc1 -UCNP-Lipo纳米系统表现出诸如容易制造，低药物剂量以及不释放亚铁离子的优点。
更新日期：2020-07-06
中文翻译：
二茂铁功能化的上转换纳米粒子纳米系统具有有效的近红外光促进芬顿样反应抑制肿瘤生长。
通过利用近红外（NIR）响应的镧系元素掺杂的上转换纳米粒子（UCNP）和Fenton试剂二茂铁基化合物（Fc）之间的有效Förster共振能量转移（FRET），通过功能化NaYF设计了一系列Fc -UCNP 4：通过表面配位化学方法，具有Fc1 - Fc5的Yb，Tm纳米颗粒。然后通过将Fc -UCNP封装在脂质体内以有效递送来构建Fc -UCNP-Lipo纳米系统。Fc -UCNP可通过NIR促进的Fenton样反应有效释放·OH 。体外和体内研究FC1 -UCNP-前列证实在肿瘤部位，随后癌细胞的增强吸收的优先积累。细胞内化后，释放的Fc1- UCNP可有效促进·OH生成，从而抑制肿瘤生长。这样的Fc1 -UCNP-Lipo纳米系统表现出诸如容易制造，低药物剂量以及不释放亚铁离子的优点。
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