光热杀菌表面：使用光而不是杀菌剂杀死细菌。,Biomaterials Science

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光热杀菌表面：使用光而不是杀菌剂杀死细菌。
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-22 , DOI: 10.1039/d0bm00617c
Yi Zou ₁ , Yanxia Zhang , Qian Yu , Hong Chen

Affiliation

赋予合成材料表面杀菌活性是防止细菌定植和生物膜形成的直接有效方法，解决了相关的污染、感染和生物污染等严重问题。传统的杀菌表面通常基于杀菌剂如抗生素来杀死附着的细菌；然而，这些表面因其各自的杀菌剂而具有固有的局限性，并且它们中的大多数对具有多重耐药性的所谓“超级细菌”的效果较差。近年来，光热杀菌表面已成为对抗表面附着细菌的有希望的替代品。这些表面依赖于固定的光热剂，可将光能转化为热能，通过各种热疗作用有效消灭细菌，具有杀菌广谱、无耐药性、副作用少等优点。在这篇综述中，我们重点介绍了这些光热杀菌表面的最新发展，根据光热剂分为三种类型。还介绍了具有集成协同杀灭机制或在杀灭细菌和释放细菌之间切换功能的多功能光热杀菌表面。最后简要介绍了对未来有希望的方向。我们重点介绍这些光热杀菌表面的最新发展，根据光热剂分为三种类型。还介绍了具有集成协同杀灭机制或在杀灭细菌和释放细菌之间切换功能的多功能光热杀菌表面。最后简要介绍了对未来有希望的方向。我们重点介绍这些光热杀菌表面的最新发展，根据光热剂分为三种类型。还介绍了具有集成协同杀灭机制或在杀灭细菌和释放细菌之间切换功能的多功能光热杀菌表面。最后简要介绍了对未来有希望的方向。

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Photothermal bactericidal surfaces: killing bacteria using light instead of biocides.

Endowing the surfaces of synthetic materials with bactericidal activity is a direct and effective way to prevent bacterial colonization and biofilm formation, solving the related serious problems such as contamination, infection and biofouling. Conventional bactericidal surfaces are usually based on biocidal agents such as antibiotics to kill attached bacteria; however, such surfaces have inherent limitations from their respective biocidal agents and most of them become less effective against the so-called “super bacteria” with multidrug-resistance. In recent years, photothermal bactericidal surfaces have become a promising alternative for combating surface-attached bacteria. These surfaces rely on immobilized photothermal agents, which can convert light energy into thermal energy to effectively eliminate bacteria through various hyperthermia effects, showing several advantages including broad-spectrum sterilization ability, no drug resistance and few side effects. In this review, we highlight the recent development of these photothermal bactericidal surfaces, which are categorized into three types according to the photothermal agents. Multi-functional photothermal bactericidal surfaces with either integrated synergistic killing mechanisms or capability to switch function between killing bacteria and releasing bacteria are also introduced. A brief perspective is finally presented on the directions that show promise for the future.

更新日期：2020-05-22

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