Metal-organic frameworks (MOFs) are a novel class of porous nanomaterials composed of metals and organic linkers that have been used in many fields. A novel stereoselective stationary phase for capillary electrochromatography (CEC) has been developed in this work by employing a biodegradable, easier-to-prepare and green homochiral MOFs (Cu-SD), which composed of octakis-[6-deoxy-6-(3-mercaptopropanoic sodium)]-γ-cyclodextrin (SD, sugammadex) and transition metal ion (Cu²⁺) supported by polydopamine as linker. The modified capillary was characterized by scanning electron microscopy (SEM), X-ray spectrometry (XRD), energy dispersive (EDS) and Fourier transform infrared spectroscopy (FT-IR). The Cu-SD modified capillary column exhibited outstanding chiral recognition separation for five Dns-DL-amino acids (the DL-forms of phenylalanine, leucine, valine, threonine, serine). In addition, the modified column showed excellent stability and reproducibility. The relative standard deviations (RSDs) of the retention time for intra-day (n = 5) and inter-day (n = 3) and between columns (n = 3) enantioseparations were less than 0.27, 1.45 and 4.88%, respectively. Conceivably, this new-type of γ-CD-MOF represents a useful chiral stationary phase in electrochromatographic separations, and it has great potential in chiral separation field.

金属有机骨架（MOF）是一类新型的由金属和有机连接物组成的多孔纳米材料，已在许多领域中使用。通过使用可生物降解的，易于制备的绿色同手性MOF（Cu-SD），该新的立体选择性固定相用于毛细管电色谱（CEC），该MOF由八-[6-脱氧-6-（ 3-巯基丙酸钠）]-γ-环糊精（SD，sugammadex）和过渡金属离子（Cu ²⁺）由聚多巴胺作为连接基支撑。通过扫描电子显微镜（SEM），X射线光谱（XRD），能量色散（EDS）和傅里叶变换红外光谱（FT-IR）对改性后的毛细管进行了表征。Cu-SD修饰的毛细管柱对五个Dns-DL-氨基酸（苯丙氨酸，亮氨酸，缬氨酸，苏氨酸，丝氨酸的DL形式）表现出出色的手性识别分离。另外，改性柱显示出极好的稳定性和可重复性。日内（n = 5）和日间（n = 3）以及两列之间（n = 3）对映体分离的保留时间的相对标准偏差（RSD）分别小于0.27、1.45和4.88％。可以想象，这种新型的γ-CD-MOF代表了电色谱分离中有用的手性固定相，