Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives contribute to reduction of cytotoxicity and suppression of drug-induced hepatic steatosis. Uridine is mostly present in blood and cerebrospinal fluid, where it contributes to the maintenance of basic cellular functions affected by UPase enzyme activity, feeding habits, and ATP depletion. Uridine metabolism depends on three stages: de novo synthesis, salvage synthesis pathway and catabolism, and homeostasis, which is tightly relating to glucose homeostasis and lipid and amino acid metabolism. This review is devoted to uridine metabolism and its role in glucose, lipid, and amino acid homeostasis.

中文翻译：

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尿苷代谢及其在葡萄糖、脂质和氨基酸稳态中的作用。


嘧啶核苷尿苷在维持细胞功能和能量代谢中起着至关重要的作用。除了在核苷合成中的作用外，尿苷及其衍生物还有助于降低细胞毒性和抑制药物诱导的肝脂肪变性。尿苷主要存在于血液和脑脊液中，有助于维持受 UPase 酶活性、饮食习惯和 ATP 消耗影响的基本细胞功能。尿苷代谢取决于从头合成、补救合成途径和分解代谢以及稳态三个阶段，与葡萄糖稳态以及脂质和氨基酸代谢密切相关。本综述致力于尿苷代谢及其在葡萄糖、脂质和氨基酸稳态中的作用。