活化白细胞粘附分子（ALCAM）在癌症进展，侵袭，转移和复发中的作用：新型癌症干细胞标记物和肿瘤特异性预后标记物。,Experimental and Molecular Pathology

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活化白细胞粘附分子（ALCAM）在癌症进展，侵袭，转移和复发中的作用：新型癌症干细胞标记物和肿瘤特异性预后标记物。
Experimental and Molecular Pathology ( IF 2.8 ) Pub Date : 2020-05-05 , DOI: 10.1016/j.yexmp.2020.104443
Behrad Darvishi ₁ , Saeedeh Boroumandieh ₁ , Keivan Majidzadeh-A ₁ , Malihe Salehi ₁ , Fereshteh Jafari ₁ , Leila Farahmand ₁

Affiliation

活化白细胞粘附分子（ALCAM）或CD166是一种100至105 KDa的跨膜免疫球蛋白，与T细胞活化，造血，嗜中性粒细胞跨内皮迁移，血管生成，炎症和肿瘤扩散以及通过形成亲和异源性而侵入互动。最近，许多研究提出ALCAM的表达模式与肿瘤的等级，阶段和侵袭性高度相关。尽管ALCAM是不同癌症中有价值的预后标志物，但是不同肿瘤类型中相似的表达模式可能与完全不同的预后状态相关，使其成为依赖肿瘤类型的预后标志物。另外，ALCAM同工型为初步检测具有转移潜力的肿瘤细胞提供了方法。更重要的是，该预后标志物已显示出极大地依赖于细胞质和膜的表达，转录后分子的间接和直接调控，促凋亡蛋白的功能以及其他几种致癌蛋白或信号通路。这篇综述主要侧重于ALCAM的表达所涉及的途径及其在不同类型癌症中的预后价值及其调控方式。

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The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker.

Activated leukocyte cell adhesion molecule (ALCAM) or CD166 is a 100 to 105 KDa transmembrane immunoglobulin which is involved in activation of T-cells, hematopoiesis, neutrophils trans-endothelial migration, angiogenesis, inflammation and tumor propagation and invasiveness through formation of homophilic and heterophilic interactions. Recently, many studies have proposed that the expression pattern of ALCAM is highly associated with the grade, stage and invasiveness of tumors. Although ALCAM is a valuable prognostic marker in different carcinomas, similar expression patterns in different tumor types may be associated with completely different prognostic states, making it to be a tumor-type-dependent prognostic marker. In addition, ALCAM isoforms provide ways for primary detection of tumor cells with metastatic potential. More importantly, this prognostic marker has shown to be considerably dependent on the cytoplasmic and membranous expression, indirect and direct regulation of post-transcriptional molecules, pro-apoptotic proteins functionalities and several other oncogenic proteins or signalling pathways. This review mainly focuses on the pathways involved in expression of ALCAM and its prognostic value of in different types of cancers and the way in which it is regulated.

更新日期：2020-05-04

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