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Multifunctional Bismuth Ferrite Nanocatalysts with Optical and Magnetic Functions for Ultrasound-Enhanced Tumor Theranostics.
ACS Nano ( IF 15.8 ) Pub Date : 2020-05-20 , DOI: 10.1021/acsnano.0c02458
Lili Feng 1, 2 , Shili Gai 1 , Fei He 1 , Piaoping Yang 1 , Yanli Zhao 2
ACS Nano ( IF 15.8 ) Pub Date : 2020-05-20 , DOI: 10.1021/acsnano.0c02458
Lili Feng 1, 2 , Shili Gai 1 , Fei He 1 , Piaoping Yang 1 , Yanli Zhao 2
Affiliation
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Ultrasound (US)-assisted oncotherapy has aroused extensive attention due to its capacities to conquer significant restrictions covering short tissue penetration depth and high phototoxicity in photoinduced therapy. We herein developed a class of pure-phase perovskite-type bimetallic oxide, namely, bismuth ferrite nanocatalysts (BFO NCs), for multimodality imaging-guided and US-enhanced chemodynamic therapy (CDT) against malignant tumors. As-prepared BFO nanoparticles with poly(ethylene glycol)-grafted phosphorylated serine (pS-PEG) modification exhibit satisfactory physiological stability and biocompatibility. The BFO NCs also present high fluorescence emission within the second near-infrared region when irradiated with an 808 nm laser. Intriguingly, the BFO NCs demonstrate highly efficient US-enhanced generation of hydroxyl free radicals, as the cavitation bubbles produced by US trigger partial grievous turbulence and promote the transfer rate of the Fenton reagents. Thus, the BFO NCs enable effective inhibition of tumor growth assisted by external US, and the treatment efficacy can be monitored by computer tomography, magnetic resonance, and fluorescence imaging. Meanwhile, H2O2 and US, as a double logic gate, activate the BFO NCs to trigger the iron-catalyzed and US-enhanced CDT with high specificity and treatment efficiency. Therefore, the BFO NCs as a theranostic agent with an enhanced chemodynamic therapeutic effect assisted by external US and a multimodality imaging capacity are put forward, which show a promising prospect for noninvasive chemodynamic oncotherapy.
中文翻译:
具有光学和磁性功能的多功能铋铁氧体纳米催化剂,用于超声增强的肿瘤治疗学。
超声(美国)辅助的肿瘤疗法因其能够克服光诱导疗法中短组织穿透深度和高光毒性的重大限制而引起了广泛关注。本文中,我们开发了一种纯相钙钛矿型双金属氧化物,即铋铁氧体纳米催化剂(BFO NCs),用于针对恶性肿瘤的多模态成像引导和US增强化学动力学治疗(CDT)。制备的具有聚(乙二醇)接枝的磷酸化丝氨酸(pS-PEG)修饰的BFO纳米粒子表现出令人满意的生理稳定性和生物相容性。当用808 nm激光照射时,BFO NC在第二个近红外区域内也呈现高荧光发射。有趣的是,BFO NC证明了美国增强了羟基自由基的高效生成,因为US产生的空化气泡会触发部分剧烈湍流并提高Fenton试剂的传输速率。因此,BFO NCs可以在外部US辅助下有效抑制肿瘤生长,并且可以通过计算机断层扫描,磁共振和荧光成像监测治疗效果。同时,H2 O 2和US作为双逻辑门,可激活BFO NC,以高特异性和治疗效率触发铁催化和US增强的CDT。因此,提出了BFO NCs作为一种治疗手段,在外源性US辅助下具有增强的化学动力学治疗效果,并具有多模态成像能力,为无创化学动力学肿瘤治疗显示了广阔的前景。
更新日期:2020-06-23
中文翻译:
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具有光学和磁性功能的多功能铋铁氧体纳米催化剂,用于超声增强的肿瘤治疗学。
超声(美国)辅助的肿瘤疗法因其能够克服光诱导疗法中短组织穿透深度和高光毒性的重大限制而引起了广泛关注。本文中,我们开发了一种纯相钙钛矿型双金属氧化物,即铋铁氧体纳米催化剂(BFO NCs),用于针对恶性肿瘤的多模态成像引导和US增强化学动力学治疗(CDT)。制备的具有聚(乙二醇)接枝的磷酸化丝氨酸(pS-PEG)修饰的BFO纳米粒子表现出令人满意的生理稳定性和生物相容性。当用808 nm激光照射时,BFO NC在第二个近红外区域内也呈现高荧光发射。有趣的是,BFO NC证明了美国增强了羟基自由基的高效生成,因为US产生的空化气泡会触发部分剧烈湍流并提高Fenton试剂的传输速率。因此,BFO NCs可以在外部US辅助下有效抑制肿瘤生长,并且可以通过计算机断层扫描,磁共振和荧光成像监测治疗效果。同时,H2 O 2和US作为双逻辑门,可激活BFO NC,以高特异性和治疗效率触发铁催化和US增强的CDT。因此,提出了BFO NCs作为一种治疗手段,在外源性US辅助下具有增强的化学动力学治疗效果,并具有多模态成像能力,为无创化学动力学肿瘤治疗显示了广阔的前景。