A point mutation in the β-adrenergic-like octopamine receptor: possible association with amitraz resistance.,Pest Management Science

当前位置： X-MOL 学术 › Pest Manag. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A point mutation in the β-adrenergic-like octopamine receptor: possible association with amitraz resistance.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-05-19 , DOI: 10.1002/ps.5921
Mizuki Takata ₁ , Seishi Misato ₁ , Fumiyo Ozoe ₁ , Yoshihisa Ozoe ₁

Affiliation

Amitraz is a unique formamidine‐class acaricide/insecticide that effectively controls ticks, mites, and insect pests. However, the recent emergence of amitraz‐resistant cattle ticks is a serious problem that requires an urgent solution. A nonsynonymous single nucleotide polymorphism (A181T) leading to an amino acid substitution (I61F) in the β‐adrenergic‐like (β‐AL) octopamine receptor (OAR) of amitraz‐resistant southern cattle ticks (Rhipicephalus microplus) (RmβAOR) was proposed to be a cause of the amitraz resistance. However, it remains unclear whether this substitution exerts any functional effect on the action of amitraz. To make this clear, the functional role of this mutation was examined using an orthologous OAR (BmOAR2) from the silkworm (Bombyx mori).

中文翻译：

β-肾上腺素样章鱼胺受体中的点突变：可能与阿米曲唑耐药有关。

Amitraz是一种独特的甲am类杀螨剂/杀虫剂，可有效控制tick虫，螨虫和害虫。但是，最近出现的抗甲虫的牛tick是一个严重的问题，需要紧急解决。提出了一种非同义的单核苷酸多态性（A181T），可导致耐阿米特拉斯的南部牛壁虱（Rhipicephalus microplus）（RmβAOR）的β-肾上腺素样（β-AL）章鱼胺受体（OAR）中发生氨基酸取代（I61F）。成为抗阿米特拉斯的原因。但是，目前尚不清楚这种取代是否对阿米特拉作用发挥任何功能作用。为了清楚起见，使用来自家蚕（Bombyx mori）的直系同源OAR（BmOAR2）检查了此突变的功能作用。

更新日期：2020-05-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南