Mussel‐Inspired Surface Acrylation on Graphene Oxide Using Acrylic Surface Primers and Its Hydrogel‐Based Applications: Sustained Drug Release and Tissue Scaffolds,ChemistrySelect

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Mussel‐Inspired Surface Acrylation on Graphene Oxide Using Acrylic Surface Primers and Its Hydrogel‐Based Applications: Sustained Drug Release and Tissue Scaffolds
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-05-19 , DOI: 10.1002/slct.202000205
Kyu Ha Park ₁ , Jaewon Jung ₁ , Sang‐Gu Yim ₁ , Mi Ju Kang ₁ , Gibum Kwon ₂ , Dae Youn Hwang ₁ , Seung Yun Yang ₁ , Sungbaek Seo ₁

Affiliation

Composite hydrogels integrated with graphene oxide were prepared to enable the sustained release of loads for graphene‐based aromatic drug delivery and enhanced cell adhesion for tissue scaffolds. The surface of graphene oxide was readily transformed by the adsorption of acrylic surface primer (SP) without chemical reactions. The surface modification was verified by energy dispersive X‐ray spectroscopy and X‐ray diffraction spectra. The acrylated graphene oxide (SP‐GO) was photocrosslinked with acrylate groups of poly(ethylene glycol) to generate a composite hydrogel (SP‐GO hydrogel). Based on the molecular weight of poly(ethylene glycol), the hydrogels showed a swelling ratio range of ∼5–20, respectively. The SP‐GO did not change noticeably mechanical properties and inner structures of the hydrogels. Aromatic doxorubicin (DOX) was entrapped in the hydrogels with good yield and demonstrates the potential for a drug delivery carrier. The released DOX from the hydrogel containing SP‐GO (70.56% of entrapped DOX) exhibited a sustained release profile with reduced release after five days in a wet environment compared to the released DOX from a hydrogel without SP‐GO (92.29% of entrapped DOX). DOX is supposed to be attracted to graphene oxide and is physically entrapped inside the hydrogels. Moreover, bone MG‐63 cells entrapped in the SP‐GO hydrogel showed increased TGF‐β and fibronectin expression levels. This implies that SP‐GO contributes to enhancing cell growth and adhesion by providing cell‐laid structural support.

中文翻译：

贻贝启发使用丙烯酸表面底漆在氧化石墨烯上进行表面丙烯酸酯化及其基于水凝胶的应用：持续释放药物和组织支架

制备了与氧化石墨烯集成的复合水凝胶，以能够持续释放负载以进行基于石墨烯的芳香族药物递送，并增强组织支架的细胞粘附性。氧化石墨烯的表面很容易通过丙烯酸表面底漆（SP）的吸附而发生转化，而没有发生化学反应。通过能量色散X射线光谱和X射线衍射光谱验证了表面改性。丙烯酸化石墨烯氧化物（SP-GO）与聚（乙二醇）丙烯酸酯基团光交联，生成复合水凝胶（SP-GO水凝胶）。基于聚乙二醇的分子量，水凝胶的溶胀比范围分别为约5-20。SP‐GO并没有明显改变水凝胶的机械性能和内部结构。芳香阿霉素（DOX）以高收率包埋在水凝胶中，证明了药物输送载体的潜力。与不含SP-GO的水凝胶中释放出的DOX相比，含有SP-GO的水凝胶中释放出的DOX（占包被的DOX的70.56％）在五天后表现出持续释放的特征，并具有减少的释放（占捕获的DOX的92.29％））。DOX可能被氧化石墨烯吸引，并被物理截留在水凝胶中。此外，截留在SP-GO水凝胶中的骨骼MG-63细胞显示TGF-β和纤连蛋白表达水平增加。这意味着SP‐GO通过提供细胞铺展的结构支持，有助于促进细胞生长和粘附。与不含SP-GO的水凝胶中释放出的DOX相比，含有SP-GO的水凝胶中释放出的DOX（占包被的DOX的70.56％）在五天后表现出持续释放的特征，并具有减少的释放（占捕获的DOX的92.29％）。DOX可能被氧化石墨烯吸引，并被物理截留在水凝胶中。此外，截留在SP-GO水凝胶中的骨骼MG-63细胞显示TGF-β和纤连蛋白表达水平增加。这意味着SP‐GO通过提供细胞铺展的结构支持，有助于促进细胞生长和粘附。与不含SP-GO的水凝胶中释放出的DOX相比，含有SP-GO的水凝胶中释放出的DOX（占包被的DOX的70.56％）在五天后表现出持续释放的特征，并具有减少的释放（占捕获的DOX的92.29％）。DOX可能被氧化石墨烯吸引，并被物理截留在水凝胶中。此外，截留在SP-GO水凝胶中的骨骼MG-63细胞显示TGF-β和纤连蛋白表达水平增加。这意味着SP‐GO通过提供细胞铺展的结构支持，有助于促进细胞生长和粘附。DOX可能被氧化石墨烯吸引，并被物理截留在水凝胶中。此外，截留在SP-GO水凝胶中的骨骼MG-63细胞显示TGF-β和纤连蛋白表达水平增加。这意味着SP‐GO通过提供细胞铺展的结构支持，有助于促进细胞生长和粘附。DOX可能被氧化石墨烯吸引，并被物理截留在水凝胶中。此外，截留在SP-GO水凝胶中的骨骼MG-63细胞显示TGF-β和纤连蛋白表达水平增加。这意味着SP‐GO通过提供细胞铺展的结构支持，有助于促进细胞生长和粘附。

更新日期：2020-05-19

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