Thiol-Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers.,ChemBioChem

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Thiol-Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-05-18 , DOI: 10.1002/cbic.202000303
Raju Bej ₁ , Arijit Ghosh ₂ , Jayita Sarkar ₁ , Benu Brata Das ₂ , Suhrit Ghosh ₁

Affiliation

It takes two: Pyridyl‐disulfide (Py−Ds) conjugated non‐ionic nontoxic polymers exhibit cellular uptake by thiol‐disulfide exchange with exofacial cell‐surface thiols without going through the endocytosis pathway. Control experiments establish essential role of the Py−Ds group as neither pyridine‐ nor an aliphatic disulfide‐appended polymer shows similar cellular uptake.

中文翻译：

巯基-二硫键交换反应促进了吡啶基二硫键附加非离子聚合物的高效细胞吸收。

它需要两个过程：吡啶基二硫键（Py-Ds）共轭的非离子型无毒聚合物表现出通过巯基二硫键与牙周细胞表面硫醇的交换而吸收细胞，而没有经过内吞途径。对照实验确定了Py-Ds基团的基本作用，因为吡啶或脂肪族二硫键连接的聚合物均未显示出相似的细胞摄取。

更新日期：2020-05-18

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