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Prevalence and Risk Factors of Moderate-to-Severe Hepatic Steatosis in Human Immunodeficiency Virus Infection: The Copenhagen Co-morbidity Liver Study.
The Journal of Infectious Diseases ( IF 5.0 ) Pub Date : 2020-05-16 , DOI: 10.1093/infdis/jiaa246 Ditte Marie Kirkegaard-Klitbo 1 , Andreas Fuchs 2 , Stefan Stender 3 , Per Ejlstrup Sigvardsen 2 , Jørgen Tobias Kühl 2 , Klaus Fuglsang Kofoed 2, 4 , Lars Køber 2 , Børge G Nordestgaard 5, 6 , Flemming Bendtsen 7 , Amanda Mocroft 8 , Jens Lundgren 9, 10 , Susanne Dam Nielsen 9 , Thomas Benfield 1
The Journal of Infectious Diseases ( IF 5.0 ) Pub Date : 2020-05-16 , DOI: 10.1093/infdis/jiaa246 Ditte Marie Kirkegaard-Klitbo 1 , Andreas Fuchs 2 , Stefan Stender 3 , Per Ejlstrup Sigvardsen 2 , Jørgen Tobias Kühl 2 , Klaus Fuglsang Kofoed 2, 4 , Lars Køber 2 , Børge G Nordestgaard 5, 6 , Flemming Bendtsen 7 , Amanda Mocroft 8 , Jens Lundgren 9, 10 , Susanne Dam Nielsen 9 , Thomas Benfield 1
Affiliation
BACKGROUND
People living with HIV (PWH) may be at risk of non-alcoholic fatty liver disease (NAFLD). We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with HIV-uninfected controls and determined risk factors for M-HS in PWH.
METHODS
The Copenhagen Co-Morbidity in HIV infection Study included 453 participants and the Copenhagen General Population Study 765 participants. None had prior or current viral hepatitis or excessive alcohol intake. M-HS was assessed by unenhanced CT liver scan defined by liver attenuation ≤48 Hounsfield units. Adjusted odds ratios (aOR) were computed by adjusted logistic regression.
RESULTS
The prevalence of M-HS was lower in PWH compared to uninfected controls (8.6% vs. 14.2%, p<0.01). In multivariable analyses, HIV (aOR:0.44, p<0.01); female sex (aOR:0.08, p=0.03); physical activity level (aOR 0.09 very active vs inactive, p<0.01); and alcohol (aOR:0.89 per unit/week, p=0.02) was protective factors, while BMI (aOR:1.58 per 1 kg/m2, p<0.01); ALT (aOR:1.76 per 10 U/L, p<0.01); and exposure to integrase inhibitors (aOR: 1.28 per year, p=0.02) were associated with higher odds of M-HS.
CONCLUSIONS
Moderate-to-severe hepatic steatosis is less common in PWH compared to demographically comparable uninfected controls. Besides BMI and ALT, integrase inhibitor exposure was associated with higher prevalence of steatosis in PWH.
中文翻译:
人类免疫缺陷病毒感染中至重度肝脂肪变性的患病率和危险因素:哥本哈根共病肝研究。
背景技术HIV感染者(PWH)可能有非酒精性脂肪肝疾病(NAFLD)的风险。我们比较了PWH中中重度肝脂肪变性(M-HS)与未感染HIV的对照的患病率,并确定了PWH中M-HS的危险因素。方法哥本哈根HIV感染合并症研究共453名参与者,哥本哈根普通人群研究共765名参与者。没有人曾经或现在患有病毒性肝炎或过量饮酒。M-HS通过未增强的CT肝脏扫描评估,其定义为肝脏衰减≤48 Hounsfield单位。通过调整后的逻辑回归来计算调整后的优势比(aOR)。结果与未感染的对照组相比,PWH中M-HS的患病率较低(8.6%比14.2%,p <0.01)。在多变量分析中,HIV(aOR:0.44,p <0.01);女性(aOR:0.08,p = 0.03); 身体活动水平(活跃或不活跃的aOR 0.09,p <0.01);酒精(aOR:每单位/周0.89,p = 0.02)是保护因子,而BMI(aOR:每1 kg / m2 1.58,p <0.01);ALT(aOR:每10 U / L 1.76,p <0.01);暴露于整合酶抑制剂(aOR:每年1.28,p = 0.02)与M-HS发生几率较高相关。结论与人口统计学上未感染的对照相比,PWH中轻度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。02)与M-HS的较高机率相关。结论与人口学上可比较的未感染对照相比,PWH中中度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。02)与M-HS的较高机率相关。结论与人口统计学上未感染的对照相比,PWH中轻度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。
更新日期:2020-05-16
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
人类免疫缺陷病毒感染中至重度肝脂肪变性的患病率和危险因素:哥本哈根共病肝研究。
背景技术HIV感染者(PWH)可能有非酒精性脂肪肝疾病(NAFLD)的风险。我们比较了PWH中中重度肝脂肪变性(M-HS)与未感染HIV的对照的患病率,并确定了PWH中M-HS的危险因素。方法哥本哈根HIV感染合并症研究共453名参与者,哥本哈根普通人群研究共765名参与者。没有人曾经或现在患有病毒性肝炎或过量饮酒。M-HS通过未增强的CT肝脏扫描评估,其定义为肝脏衰减≤48 Hounsfield单位。通过调整后的逻辑回归来计算调整后的优势比(aOR)。结果与未感染的对照组相比,PWH中M-HS的患病率较低(8.6%比14.2%,p <0.01)。在多变量分析中,HIV(aOR:0.44,p <0.01);女性(aOR:0.08,p = 0.03); 身体活动水平(活跃或不活跃的aOR 0.09,p <0.01);酒精(aOR:每单位/周0.89,p = 0.02)是保护因子,而BMI(aOR:每1 kg / m2 1.58,p <0.01);ALT(aOR:每10 U / L 1.76,p <0.01);暴露于整合酶抑制剂(aOR:每年1.28,p = 0.02)与M-HS发生几率较高相关。结论与人口统计学上未感染的对照相比,PWH中轻度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。02)与M-HS的较高机率相关。结论与人口学上可比较的未感染对照相比,PWH中中度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。02)与M-HS的较高机率相关。结论与人口统计学上未感染的对照相比,PWH中轻度至重度肝脂肪变性较不常见。除BMI和ALT外,整合酶抑制剂的暴露与PWH中脂肪变性的患病率更高有关。