Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.,Journal of Internal Medicine

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Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.
Journal of Internal Medicine ( IF 9.0 ) Pub Date : 2020-05-16 , DOI: 10.1111/joim.13095
P Simonen ₁ , S Li _{2,

3} , N K Chua ₄ , A-M Lampi ₅ , V Piironen ₅ , J Lommi ₁ , J Sinisalo ₁ , A J Brown ₄ , E Ikonen _{2,

3} , H Gylling ₆

Affiliation

We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism.

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