由季铵化 N-[3(二甲氨基)丙基] 甲基丙烯酰胺共聚物制备自修复水凝胶，用于抗菌和药物释放应用。,Journal of Biomedical Materials Research Part A

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由季铵化 N-[3(二甲氨基)丙基] 甲基丙烯酰胺共聚物制备自修复水凝胶，用于抗菌和药物释放应用。
Journal of Biomedical Materials Research Part A ( IF 3.9 ) Pub Date : 2020-05-17 , DOI: 10.1002/jbm.a.37005
Heng An ₁ , Yan Yang ₂ , Yunyi Bo ₂ , Xiangbo Ma ₃ , Yong Wang ₃ , Longmei Liu ₄ , Haijun Wang ₁ , Yingna He ₂ , Jianglei Qin _{1,

3}

Affiliation

近年来，自修复水凝胶因其在生物科学和生物技术中的广泛应用而备受关注。在本研究中，P(DMAPMA- stat -DAA) 通过可逆加成-断裂链转移 (RAFT) 聚合合成并季铵化以导入抗菌性能。然后季化 P(DMAPMA- stat‐DAA) 用于制备含有酰腙基团的水凝胶，其中聚环氧乙烷 (PEO) 二酰肼作为交联剂。酰基腙基团赋予水凝胶多种特性，包括基团响应性和自愈特性。同时，季铵盐赋予水凝胶抗菌性能。深入研究了水凝胶的机械性能、自愈性能和抗菌性能。_{结果表明水凝胶在中性条件下形成，PEO 23}引入了发光特性二萘酰肼（DNH）交联。水凝胶显示出受控的 pH 敏感 DOX·HC l 和卵清蛋白 (OVA) 释放曲线。此外，水凝胶显示出抗菌性能，在不久的将来可能在生物医学领域有重要应用。

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Fabrication of self-healing hydrogel from quaternized N-[3(dimethylamino)propyl]methacrylamide copolymer for antimicrobial and drug release applications.

Self‐healing hydrogels have attracted great attention in recent years because of their wide application in bioscience and biotechnology. In this study, P(DMAPMA‐stat‐DAA) were synthesized by Reversible Addition‐Fragmentation Chain Transfer (RAFT) polymerization and quaternized to import antimicrobial properties. Then quaternized P(DMAPMA‐stat‐DAA) was used to prepare hydrogel containing acylhydrazone groups with Polyethylene oxide (PEO) diacylhydrazide as a cross‐linking agent. The acylhydrazone groups imparted a variety of properties, including group responsiveness and self‐healing properties to the hydrogel. At the same time, the quaternary ammonium endowed the hydrogel with the antimicrobial property. The mechanical property, self‐healing properties, and antimicrobial property of hydrogels were investigated intensively. Results showed hydrogels formed in neutral conditions, and the luminescent property was introduced with PEO₂₃ dinaphthhydrazide (DNH) cross‐linking. The hydrogels showed a controlled pH‐sensitive DOX·HC l and Ovalbumin (OVA) release profile. In addition, the hydrogel showed the antimicrobial property and may have important applications in the biomedical field in the near future.

更新日期：2020-05-17

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